64172-41-4Relevant academic research and scientific papers
CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
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Page/Page column 24, (2015/01/16)
The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon
Rosini, Michela,Simoni, Elena,Bartolini, Manuela,Soriano, Elena,Marco-Contelles, Jose,Andrisano, Vincenza,Monti, Barbara,Windisch, Manfred,Hutter-Paier, Birgit,Mcclymont, David W.,Mellor, Ian R.,Bolognesi, Maria Laura
supporting information, p. 1276 - 1281 (2013/08/23)
Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds also enhanced the survival of chicken neurons under apoptosis-inducing conditions. Copyright
Hexahydro-γ-carboline derivatives and their salts
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, (2008/06/13)
Hexahydro-γ-carboline derivatives of the formula: SPC1 Wherein R1 is methyl or ethyl, and R2 is hydrogen, methyl or ethyl, with proviso that when R1 is ethyl, R2 is hydrogen, and their pharmaceutically acceptabl
