64173-01-9

Upstream product

• 64173-00-8 4-carbobenzyloxy-1-(2-nitrophenyl)-piperazine-2-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 67889-51-4 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper 
• 934630-06-5 4-(benzyloxy-carbonyl)-2-piperazinecarboxylic acid 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 444161-48-2 benzyl 8-bromo-5-oxo-1,2,4,4a,5,6-hexahydro-3H-pyrazino-[1,2-a]quinoxaline-3-carboxylate 
• 75704-19-7 2,3,4,4a-tetrahydro-1H-pyrazino<1,2a>quinoxalin-5(6H)-one 
• 304023-32-3 6-methyl-5-oxo-1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinoxaline-3-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them

Compounds of formula (I): wherein A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring,n and n′ represent 0, 1 or 2X represents an alkylene chain as defined in the description,R3 represents an aryl or heteroaryl group,one of the groups R1 and R2 represents a hydrogen atom and the other represents a group of formula (II) as defined in the description. Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.

Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinozalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino [1,2-,a] quinoxalines

A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro- 1H-pyrazino[1,2-a]-quinoxalines was shown to exhibit 5-HT(2C) agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague-Dawley rats with ED50 values of 2 mg/kg (ip) and 10 mg/kg (po). (C) 2000 Elsevier Science Ltd.

2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Compounds of the formula STR1 wherein R is hydrogen (lower)alkyl, phen(lower)alkyl, benzoyl(lower)alkyl, or p-halobenzoyl(lower)alkyl; R1 is hydrogen or (lower)alkyl; R2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R3 is hydrogen, or (lower)alkyl; and R4 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hypotensive effect in hypertensive animals.