64173-09-7Relevant academic research and scientific papers
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents
Peng, Fei,Wang, Guangcheng,Li, Xiuxia,Cao, Dong,Yang, Zhuang,Ma, Liang,Ye, Haoyu,Liang, Xiaolin,Ran, Yan,Chen, Jinying,Qiu, Jingxiang,Xie, Caifeng,Deng, Chongyang,Xiang, Mingli,Peng, Aihua,Wei, Yuquan,Chen, Lijuan
, p. 272 - 280 (2012/09/07)
24 derivatives (5a-x) derived from natural pyranochalcones (I and II) were designed and evaluated for their inhibitory potency on the production of nitric oxide (NO) in LPS-stimulated RAW264.7 cells. Among them, four compounds (5b, 5d, 5f, and 5h) exhibit
Isolation and synthesis of chalcones with different degrees of saturation
Krohn, Karsten,Steingr?ver, Klaus,Srinivasa Rao
, p. 931 - 936 (2007/10/03)
Crotaoprostrin, a chalcone not yet known as a plant constituent, was isolated from the aerial parts of the Indian medicinal plant Crotalaria prostrata. The structures of the chalcone polyarvin and the partially hydrogenated naturally occurring derivatives
Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
Nicolaou,Pfefferkorn,Roecker,Cao,Barluenga,Mitchell
, p. 9939 - 9953 (2007/10/03)
Herein we report a novel strategy for the design and construction of natural and natural product-like libraries based on the principle of privileged structures, a term originally introduced to describe structural motifs capable of interacting with a variety of unrelated molecular targets. The identification of such privileged structures in natural products is discussed, and subsequently the 2,2-dimethylbenzopyran moiety is selected as an inaugural template for the construction of natural product-like libraries via this strategy. Initially, a novel solid-phase synthesis of the benzopyran motif is developed employing a unique cycloloading strategy that relies on the use of a new, polystyrene-based selenenyl bromide resin. Once the loading, elaboration, and cleavage of these benzopyrans was established, this new solid-phase method was then thoroughly validated through the construction of six focused combinatorial libraries designed around natural and designed molecules of recent biological interest.
