24672-84-2 Usage
Uses
Used in Pharmaceutical Industry:
Ethanone,1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)is used as a key intermediate in the synthesis of pyranocoumarins, which are a group of naturally occurring compounds with diverse biological activities. These pyranocoumarins have been found to possess various pharmacological properties, such as anti-inflammatory, antifungal, and anticoagulant effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, Ethanone,1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)is used as a starting material for the preparation of chromene derivatives. These chromene derivatives have been identified as potential inhibitors of HSP90, a protein that plays a crucial role in the stabilization and folding of other proteins. Inhibiting HSP90 has been shown to have therapeutic potential in the treatment of various diseases, including cancer.
Used in Drug Development:
Ethanone,1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)may also be utilized in drug development, particularly in the design and synthesis of novel compounds with potential therapeutic applications. Its unique chemical structure allows for the exploration of various chemical modifications, which could lead to the discovery of new drugs with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 24672-84-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,6,7 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24672-84:
(7*2)+(6*4)+(5*6)+(4*7)+(3*2)+(2*8)+(1*4)=122
122 % 10 = 2
So 24672-84-2 is a valid CAS Registry Number.
24672-84-2Relevant academic research and scientific papers
A One-Pot Synthesis of Pyranocoumarins Through Microwave-Promoted Propargyl Claisen Rearrangement/Wittig Olefination
Schmidt, Bernd,Schultze, Christiane
supporting information, p. 223 - 227 (2018/01/26)
The reaction between propargyl ethers of hydroxybenzaldehydes and the ylide ethyl (triphenylphosphoranylidene)acetate was carried out under microwave irradiation to regioselectively afford angular pyranocoumarins. The chromene and coumarin heterocyclic scaffolds were simultaneously formed in the same synthetic step without changing the reaction conditions. The natural products seselin, braylin, and dipetalolactone were among the products synthesized by this method.
Anti-AIDS agents 83. Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds
Zhou, Ting,Shi, Qian,Lee, Kuo Hsing
experimental part, p. 4382 - 4386 (2010/09/12)
A novel and efficient microwave-assisted one-pot reaction was developed to synthesize angular 2,2-dimethyl-2H-chromone-containing compounds, which is the first and key step in the synthesis of potent DCK and DCP anti-HIV agents. The newly developed microwave synthesis conditions dramatically shortened the reaction time from 2 days to 4 h with improved yields.
Isolation and synthesis of chalcones with different degrees of saturation
Krohn, Karsten,Steingr?ver, Klaus,Srinivasa Rao
, p. 931 - 936 (2007/10/03)
Crotaoprostrin, a chalcone not yet known as a plant constituent, was isolated from the aerial parts of the Indian medicinal plant Crotalaria prostrata. The structures of the chalcone polyarvin and the partially hydrogenated naturally occurring derivatives
