64179-08-4

Upstream product

• 61380-85-6 6-phenyl-3-cyano-4-methylsulfanyl-2H-pyran-2-one 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 1215114-73-0 2-(4-bromo-1,3-diphenyl-1H-pyrazol-5-yl)acetonitrile 
• 700862-93-7 4-cyano-1,3-diphenyl-5-methylthio-6,7,8,9-tetrahydro-3H-benzo[e]indazole 
• 700863-01-0 4-cyano-1,3-diphenyl-5-methylthio-6,7-dihydro-3H-naphtho[1,2-e]indazole 
• 700862-98-2 4-cyano-1,3-diphenyl-5-methylthio-3,6-dihydroindeno[1,2-e]indazole 

Relevant academic research and scientific papers

Chemical transformations on 6-aryl-3-cyano4-methylthio-pyran-2(h)-ones: Synthetic and structural studies on novel N-phenylpyrazoles and N-phenylpyrazolylcoumarins

Seven 6-aryl-3-cyano-4-methylthiopyran-2(H)ones 1-7 have been prepared and used for the efficient synthesis of twelve 1,3-diaryl-5-cyanomethylpyrazoles 8-19, one 3-cyanomethyl-5-(3,4-methylenedioxyphenyl)pyrazole 22 and one 5-cyanomethyl-3-phenylisoxazole

Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants

A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.