61380-85-6Relevant academic research and scientific papers
Imaging and Quantitative Detection of Lipid Droplets by Yellow Fluorescent Probes in Liver Sections of Plasmodium Infected Mice and Third Stage Human Cervical Cancer Tissues
Sharma, Ashutosh,Jha, Ajay K.,Mishra, Shachi,Jain, Ankita,Chauhan, Bhavana S.,Kathuria, Manoj,Rawat, Kundan S.,Gupta, Neeraj M.,Tripathi, Renu,Mitra, Kalyan,Sachdev, Monika,Bhatt, Madan L. B.,Goel, Atul
, p. 3606 - 3613 (2018)
The diagnosis and prognosis of the disease associated with lipid irregularity are areas of extreme significance. In this direction, fluoranthene based yellow fluorescent probes (FLUN-550, FLUN-552, FLUN-547) were designed and synthesized by conjugating th
Design and synthesis of new functionalized 8-(thiophen-2-yl)-1,2,3,4-tetrahydroquinolines as turn-off chemosensors for selective recognition of Pd2+ions
Shally,Kumar, Vijay,Althagafi, Ismail,Kumar, Ashish,Singhal, Divya,Kumar, Abhinav,Gupta, Rajeev,Pratap, Ramendra
, p. 15559 - 15566 (2020)
We have developed two novel chemosensors 6-morpholino-8-(thiophen-2-yl)-1,2,3,4-tetrahydroquinoline-5-carbonitrile (L1) and 6-(methylthio)-8-(thiophen-2-yl)-1,2,3,4-tetrahydroquinoline-5-carbonitrile (L2) for selective identification of highly toxic Pd2+
Metal-Free Synthesis of Biaryl- and Teraryl-Cored Diarylmethanes by Ring Transformation of 2 H -Pyran-2-ones
Singh, Fateh V.,Kole, Priyanka B.
, p. 1435 - 1444 (2019)
An efficient metal-free approach for the synthesis of functionalized biaryl-cored diarylmethanes is described by the ring transformation of 2 H -pyran-2-ones using 4-phenylbutan-2-one as carbanion source. Moreover, 2 H -pyran-2-ones were reacted with 1,3-
Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines
Kennedy, L. John,Singh, Fateh V.,Subashini, C.
, (2020/10/18)
A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under
Design, synthesis, in vitro and in vivo biological evaluation of pyranone-piperazine analogs as potent antileishmanial agents
Mishra, Shachi,Parmar, Naveen,Chandrakar, Pragya,Sharma, Chandra Prakash,Parveen, Sajiya,Vats, Ravi P.,Seth, Anuradha,Goel, Atul,Kar, Susanta
, (2021/05/17)
The current therapeutic regimen for visceral leishmaniasis is inadequate and unsatisfactory due to toxic side effects, high cost and emergence of drug resistance. Alternative, safe and affordable antileishmanials are, therefore, urgently needed and toward these we synthesized a series of arylpiperazine substituted pyranone derivatives and screened them against both in vitro and in vivo model of visceral leishmaniasis. Among 22 synthesized compounds, 5a and 5g showed better activity against intracellular amastigotes with an IC50 of 11.07 μM and 15.3 μM, respectively. In the in vivo, 5a significantly reduced hepatic and splenic amastigotes burden in Balb/c mice model of visceral leishmaniasis. On a mechanistic node, we observed that 5a induced direct Leishmania killing via mitochondrial dysfunction like cytochrome c release and loss of membrane potential. Taken together, our results suggest that 5a is a promising lead for further development of antileishmanial drugs.
Base-mediated alternate route for multi-functionalized allylbenzenes using ring transformation strategy
Shetgaonkar, Samata E.,Singh, Fateh V.
, p. 2511 - 2521 (2020/07/09)
A simple yet innovative approach for the construction of multi-substituted allylbenzenes 14, 16 and 18 with ‘donor-acceptor’ functionalities has been delineated through base-mediated ring transformation of 6-aryl-2H-pyran-2-ones 13, 15 and 17 respectively
Transition metal-free synthesis of sterically hindered allylarenes from 5-hexene-2-one
Althagafi, Ismail,Elagamy, Amr,Nemaysh, Vishal,Pratap, Ramendra,Rai, Reeta,Shah, Chandan,Shaw, Ranjay,Singh, Harpreet
supporting information, p. 6276 - 6286 (2020/09/07)
A simple, efficient and transition metal-free strategy was established for the synthesis of highly functionalized, sterically hindered allylarenes (6, 7 & 8) by base-mediated ring transformation of 2-oxo-6-aryl-4-(methylthio/sec-amino)-2H-pyran-3-carbonit
A [5 + 1] annulation strategy for the synthesis of multifunctional biaryls and: P -teraryls from 1,6-Michael acceptor ketene dithioacetals
Althagafi, Ismail,Elagamy, Amr,Kumar, Abhinav,Pratap, Ramendra,Shally,Shaw, Ranjay
, p. 6407 - 6417 (2020/09/07)
A new type of ketene dithioacetal, 2-(3,3-bis-methylsulfanyl-1-arylallylidene)malononitriles containing 1,4 and 1,6-Michael acceptors, were synthesized to study their reactivity for the synthesis of a new molecular entity. We report a [5 + 1] annulation s
Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone
Shally,Althagafi, Ismail,Singhal, Divya,Panwar, Rahul,Shaw, Ranjay,Elagamy, Amr,Pratap, Ramendra
, (2019/11/11)
An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection
A Metal-Free Approach for the Synthesis of 2-Tetralones via Carbanion-Induced Ring Transformation of 2 H -Pyran-2-ones
Shetgaonkar, Samata E.,Singh, Fateh V.
, p. 3540 - 3548 (2018/09/04)
A metal-free, ultrasound-assisted approach for the synthesis of highly functionalized 2-tetralones in high yields is described. The process involves ring transformation of 2 H -pyran-2-ones with the spirocyclic ketone 1,4-cyclohexandione monoethylene keta
