64181-46-0Relevant academic research and scientific papers
Nitrate-promoted Selective C-H Fluorination of Benzamides and Benzeneacetamides
Ning, Xing-Qian,Lou, Shao-Jie,Mao, Yang-Jie,Xu, Zhen-Yuan,Xu, Dan-Qian
supporting information, p. 2445 - 2448 (2018/04/27)
A versatile and site-selective nitrate-promoted C-H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C-H bond fluorination, which featu
Site-Selective Silylation of Aliphatic C-H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides
Liu, Pei,Tang, Jinghua,Zeng, Xiaoming
supporting information, p. 5536 - 5539 (2016/11/17)
The first example of site-selective silylation of C(sp3)-H bonds mediated by a [1,5]-hydrogen transfer is reported. This reaction occurs selectively at the α-position of benzamides with a combination of tert-butylmagnesium chloride and a catalytic amount of 4,4′-di-tert-butylbipyridine (dtbpy) ligand and provides a facile route for the creation of biologically interesting α-sila benzamides. Late-stage functionalization of the incorporated silyl moieties facilitates the synthesis of N-formyl, cis-enamine, β-hydroxyl, amino, and pyrrole-containing derivatives.
Oxidative amidation of aldehydes and alcohols with primary amines catalyzed by KI-TBHP
Rajender Reddy,Uma Maheswari,Venkateshwar,Lakshmi Kantam
supporting information; experimental part, p. 3619 - 3622 (2009/05/07)
Oxidative amidation of aldehydes and alcohols with amines to afford the corresponding amides in excellent yields and ee values over 98% is achieved by using a catalytic amount of KI in combination with TBHP as the external oxidant. This method avoids the use of expensive and/or air-sensitive reagents. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
