64183-86-4Relevant academic research and scientific papers
Preparative Optical Resolution of Axial- and Planar-chiral Benzene Derivatives, Metallocenes, and Methanoazaannulenes by Medium Pressure Chromatography on Triacetylcellulose
Schloegl, Karl,Widhalm, Michael
, p. 3042 - 3048 (2007/10/02)
Medium pressure chromatography (at 4 - 6 bar and 6 - 40 deg C) on specially prepared triacetylcellulose in ethanol (or ether) renders possible an efficient preparative optical resolution of chiral benzene derivatives, (benzene)tricarbonylchromium complexes (benchrotrenes), ferrocenes, and azaannulenes.The method is presented for 15 selected examples such as 1,3-diferrocenyl-1,3-diphenylallene (1), 2,2'-spirobiindanes (2,3), biphenyl derivatives (4 - 8) and their tricarbonylchromium complexes (9 - 11), metacyclophanes (12 - 14) and 2,7-methanoazaannulenes (15,16) as well as for Troeger's base.In ten cases a quantitative separation of the enantiomers and in two an appr. 80 percent enantiomeric enrichment was achieved whereas for three compounds only a partial resolution took place.
