64190-94-9 Usage
Description
Zanthobungeanine is a naturally occurring alkaloid compound found in the plant Zanthoxylum bungeanum, commonly known as Sichuan pepper. It is a benzophenanthridine alkaloid with potential anti-inflammatory and antimicrobial properties. Zanthobungeanine has been isolated and studied for its potential pharmaceutical uses due to its ability to inhibit interleukin-1β-induced prostaglandin E2 production and its activity against different strains of bacteria. It has also been shown to have potential anti-tumor and anti-cancer properties, making it a subject of interest for further research and development of potential therapeutic applications.
Uses
Used in Pharmaceutical Industry:
Zanthobungeanine is used as an anti-inflammatory agent for its ability to inhibit interleukin-1β-induced prostaglandin E2 production, which can help in reducing inflammation and pain.
Used in Antimicrobial Applications:
Zanthobungeanine is used as an antimicrobial agent for its activity against different strains of bacteria, which can help in treating bacterial infections.
Used in Anticancer Applications:
Zanthobungeanine is used as an anti-tumor and anti-cancer agent for its potential to inhibit the growth and progression of cancer cells, making it a promising candidate for further research and development of therapeutic applications in oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 64190-94-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,1,9 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64190-94:
(7*6)+(6*4)+(5*1)+(4*9)+(3*0)+(2*9)+(1*4)=129
129 % 10 = 9
So 64190-94-9 is a valid CAS Registry Number.
64190-94-9Relevant articles and documents
Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone
Hou, Ke-Qiang,Chen, Xue-Ping,Huang, Yiyou,Chan, Albert S. C.,Luo, Hai-Bin,Xiong, Xiao-Feng
supporting information, p. 584 - 588 (2020/02/04)
We describe herein the first asymmetric total synthesis and biological evaluation of the natural PDE4 inhibitor toddacoumalone and its stereoisomers. The key step of the total synthesis is a formal asymmetric [4 + 2] cycloaddition reaction catalyzed by chiral secondary amine catalysts. A variety of pyranoquinolinones and 3-methylcrotonaldehyde are well tolerated under the optimized reaction conditions, which paved the way for further SAR studies. Further biological evaluation showed 1a′ with the best PDE4 inhibitory activity (IC50 = 0.18 μM).
QUINOLINONE ALKALOIDS FROM AN AGATHOSMA SPECIES
Campbell, William E.,Davidowitz, Bette,Jackson, Graham E.
, p. 1303 - 1306 (2007/10/02)
The aerial parts of a new species from the genus Agathosma yielded skimmianine and two new alkaloids which were identified by means of spectral data and synthesis as 4,6-dimethoxy-1-methyl-2(1H)-quinolinone and 2,6-dihydro-9-methoxy-2,2,6-trimethyl-5H-pyr
A CONVENIENT SYNTHESIS OF FLINDERSINE, ATANINE AND THEIR ANALOGUES
Ramesh, M.,Mohan, P. S.,Shanmugam, P.
, p. 4041 - 4050 (2007/10/02)
A new synthesis of the pyranoquinolone alkaloids flindersine (8a), 8-methoxyflindersine (8c), N-methylflindersine (9a), zanthobunglanine (9c), oricine (9d) and veprisine (9e) and the prenylquinolone alkaloids atanine (13a), preskimmianine (13e), N-methylatanine (14a), O-methylglycosolone (14c) and N-methylpreskimmianine (14e) is described.
