64194-73-6

Usage

InChI:InChI=1/C19H17Cl2N5O2/c1-11-24-25-17(10-23-18(27)9-22)26(11)16-7-6-12(20)8-14(16)19(28)13-4-2-3-5-15(13)21/h2-8H,9-10,22H2,1H3,(H,23,27)

Upstream product

• 83520-19-8 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone 
• 64194-76-9 2',5-dichloro-2-<3-<(α-chloroacetamido)methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone 
• 64194-72-5 2',5-dichloro-2-<3-<<(phthaloylglycyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone 
• 64194-99-6 3-(acetylamino)-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2-<<(phthaloylglycyl)amino>methyl>qyinazoline 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 64194-98-5 N-[2-Aminomethyl-4-bromo-6-chloro-4-(2-chloro-phenyl)-4H-quinazolin-3-yl]-acetamide; hydrobromide 
• 83520-09-6 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline 
• 64194-71-4 2',5-dichloro-2-<3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone dihydrobromide 
• 83520-05-2 3-<<(benzyloxycarbonyl)glycyl>amino>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxy-2-methylquinazoline 
• 64194-97-4 3-(acetylamino)-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline 
• 83520-12-1 2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester 
• 64194-96-3 3-amino-2-<<(benzyloxycarbonyl)amino>methyl>-6-chloro-4-(2-chlorophenyl)-3,4-dihydro-4-hydroxyquinazoline 
• 83520-17-6 2',5-dichloro-2-<3-<<(benzyloxycarbonyl)amino>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone 
• 83520-08-5 2-Benzyloxycarbonylamino-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester 

Relevant academic research and scientific papers

Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones

A series of the title compounds was prepared via condensation of the 3-(aminomethyl)triazolylbenzophenone with N-protected amino acids, followed by deprotection, amination of the 3-[(chloroacetamido)methyl]triazolylbenzophenone, or reduction of the relevant azide derivative. Some of the title compounds were also derived directly from the quinazolines by acid-induced rearrangement, followed by deprotection. These new amino acid amide derivatives of the triazolylbenzophenones were evaluated for central nervous system (CNS) activity. Members of this class of compounds exhibited a high level of CNS activities. For example, 2',5-dichloro-2-[3-[(glycylamino)methyl]-5-methyl-4H-1,2,4-triazol-4-yl ]benzophenone was as active as triazolam, with an ED50 of 0.58 mg/kg (mice, po), against antifighting activity in the foot shock-induced fighting test. Other triazolylbenzophenone derivatives showed similar pharmacological activities.

Process for producing triazolylbenzophenone derivatives

Triazolylbenzophenone derivatives of the formula: STR1 (wherein R represents hydrogen, C1 -C6 alkyl, C1 -C6 halo-alkyl, the group --(CH2)n -X-R5, or the group STR2 R5

Benzophenone glycinamide derivatives

This invention is directed toward pharmacologically active compounds of the formula STR1 wherein A represents a nitrogen atom which may be substituted by a methyl, cyclopropylmethyl, di(C1-4 alkyl)aminoethyl, methoxymethyl or hydroxyethyl group and B represents a carbonyl group or A and B together represent a grouping of the formula STR2 in which Ra represents a hydrogen atom or a lower alkyl or hydroxymethyl group and X represents a nitrogen atom or C--Rb wherein Rb represents a hydrogen atom or a lower alkyl or hydroxymethyl group; R represents a halogen atom or a nitro or trifluoromethyl group; R1 represents a hydrogen atom or a lower alkyl group; R2 represents an acyl group derived from a naturally occurring amino acid (all such groups which contain an asymmetric carbon atom having the L- or D,L-configuration) and R3 represents a phenyl, halophenyl or 2-pyridyl group And acid addition salts thereof. Also provided are methods for their preparation and intermediates thereof. These compounds exhibit activity as anticonvulsants, muscle relaxants and sedatives.