83520-12-1

Basic information

• Product Name: 2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester
• CAS NO: 83520-12-1
• Molecular Weight: 542.419
• Mol File: 83520-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester(83520-12-1)
• EPA Substance Registry System: 2-(2-Benzyloxycarbonylamino-acetylamino)-N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-acetimidic acid ethyl ester(83520-12-1)

Safety Data

• Hazardous Substances Data: 83520-12-1(Hazardous Substances Data)

Upstream product

• 20855-76-9 <<(benzyloxycarbonyl)glycyl>amino>acetonitrile 
• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 
• 83520-10-9 N-(benzyloxycarbonyl)glycylglycine iminoethyl ester hydrochloride 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 

Downstream Products

• 64194-73-6 2',5-dichloro-2-(3-glycylaminomethyl-5-methyl-4H-1,2,4-triazol-4-yl)-benzophenone 
• 83520-19-8 2',5-dichloro-2-<3-<<α-<(benzyloxycarbonyl)aminol>acetamido>methyl>-5-methyl-4H-1,2,4-triazol-4-yl>benzophenone 
• 83520-09-6 3-(acetylamino)-2-<<<(benzyloxycarbonyl)glyyl>amino>methyl>-4-(2-chlorophenyl)-6-chloro-3,4-dihydro-4-hydroxyquinazoline 

Relevant articles and documents

Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones

A series of the title compounds was prepared via condensation of the 3-(aminomethyl)triazolylbenzophenone with N-protected amino acids, followed by deprotection, amination of the 3-[(chloroacetamido)methyl]triazolylbenzophenone, or reduction of the relevant azide derivative. Some of the title compounds were also derived directly from the quinazolines by acid-induced rearrangement, followed by deprotection. These new amino acid amide derivatives of the triazolylbenzophenones were evaluated for central nervous system (CNS) activity. Members of this class of compounds exhibited a high level of CNS activities. For example, 2',5-dichloro-2-[3-[(glycylamino)methyl]-5-methyl-4H-1,2,4-triazol-4-yl ]benzophenone was as active as triazolam, with an ED50 of 0.58 mg/kg (mice, po), against antifighting activity in the foot shock-induced fighting test. Other triazolylbenzophenone derivatives showed similar pharmacological activities.