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• 507-19-7 t-butyl bromide 

Relevant academic research and scientific papers

Chromium(II)-Mediated Intermolecular Free-Radical Carbon-Carbon Bond Formation

Chromium(II) complexes are found to be effective mediators for intermolecular free-radical C-C bond formation.Thus, Cr(en)2(2+) species react with alkyl halides to generate the corresponding alkyl radicals which are readily trapped with electron-deficient alkenes to afford the coupling products.Key Words: Radicals / Bond formation, C-C / Chromium(II) complexes

The Influence of Acetoxy Substituents on the Nucleophilicity of Alkyl Radicals

Reduction of the organomercuric salt 3 with NaBH4 yields the acetoxy-substituted radical 4.Using competition techniques the rel. rates of addition of 4 to alkenes 5 can be measured.The rate data show that radical 4 is a nucleophile (table 1) but the nucleophilicity is slightly smaller than that of the sec. cyclohexyl radical (figure 1).The acetoxy group, therefore, acts as an electron withdrawing substituent that reduces the nucleophilic reactivity and the nucleophilic selectivity of alkyl radicals.