641999-96-4Relevant academic research and scientific papers
A new strategy of the chemical route to the cyclopropane structure: direct transformation of benzylidenemalononitriles and malononitrile into 1,1,2,2-tetracyanocyclopropanes
Elinson, Michail N.,Feducovich, Sergey K.,Stepanov, Nikita O.,Vereshchagin, Anatolii N.,Nikishin, Gennady I.
, p. 708 - 713 (2008)
The new reaction was found: the direct formation of cyclopropanes from activated olefins and C-H acids. The action of free halogen or active halogen containing compounds on the equal amounts of benzylidenemalononitriles and malononitrile in basic alcohol
Pyridinium bromide as a new mediator for electrochemical transformations involving CH-acids
Vereshchagin, Anatoly N.,Dorofeeva, Evgeniya O.,Elinson, Michail N.,Korolev, Victor A.,Egorov, Mikhail P.
, p. 391 - 392 (2019/08/20)
Pyridinium bromide has been tested as a new mediator for electrochemical synthesis of functionalized cyclopropane from alkylidenemalononitriles and CH-acids. The process was performed in an undivided cell with the use of substoichiometric amount of PyHBr
Pyridinium bromide as a mediator in electrochemical reactions: The preparation of cyclopropane-1,1-dicarbonitriles
Vereshchagin, Anatoly N.,Dorofeeva, Evgeniya O.,Elinson, Michail N.,Egorov, Mikhail P.
, p. 325 - 335 (2020/02/13)
Pyridinium bromide has been tested as a new mediator for electrochemical transformations in methanol and acetonitrile. An efficient protocol for the synthesis of cyclopropanes via the electrochemical transformations of alkylidenemalononitriles and C-H aci
One-pot cascade assembling of 3-substituted tetracyanocyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action
Vereshchagin, Anatolii N.,Elinson, Michail N.,Stepanov, Nikita O.,Nikishin, Gennady I.
experimental part, p. 324 - 325 (2010/01/18)
The new cascade reaction was found: the formation of cyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action; the action of aqueous bromine on the equal amounts of alkylidenemalononitriles and malononitrile in EtOH-
A new type of cascade reaction: direct conversion of carbonyl compounds and malononitrile into substituted tetracyanocyclopropanes
Elinson, Michail N.,Vereshchagin, Anatolii N.,Stepanov, Nikita O.,Ilovaisky, Alexey I.,Vorontsov, Alexander Ya.,Nikishin, Gennady I.
experimental part, p. 6057 - 6062 (2011/03/19)
A new type of chemical cascade reaction was found: the direct formation of cyclopropanes from carbonyl compounds and C-H acid. The action of free halogen or active halogen containing compounds on a mixture of 1 equiv of carbonyl compound and 2 equiv of malononitrile in a basic alcohol solution results in the formation of substituted 1,1,2,2-tetracyanocyclopropanes in 15-80% yield. The latter are well-known precursors for the different bicyclic heterosystems, among them compounds containing a cyclopropane ring and possessing different types of pharmacological activity. Thus, the new, simple and efficient 'one-pot' way to substituted tetracyanocyclopropanes in 50-80% yield was found directly from such simple and reasonable starting compounds as aldehydes, or some cyclic ketones, or substituted cyclohexanones and malononitrile.
