642034-52-4Relevant academic research and scientific papers
Synthesis of some novel pyrido[2,3-d]pyrimidine derivatives and their antimicrobial investigations
Bhargava, Sangeeta,Rajwanshi, Lokesh K.
, p. 448 - 452 (2013/05/08)
A series of pyrido[2,3-d]pyrimidine derivatives viz 4-amino-5,7- disubstituted pyrido[2,3-d]pyrimidines 3a-d, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones 4a-d and 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidin-2(1H)-thione 5a-d have been synthesized by the condensation reaction of 2-amino-3-cyano-4,6-disubstituted pyridines 2a-d with formamide, urea and thiourea, respectively. The newly synthesized compounds have been established by elemental analysis, IR, 1H and 13C NMR. All the synthesized compounds have been screened for their antibacterial and antifungal activity.
One-pot synthesis of 4,6-Diaryl-2-oxo(imino)-1,2-dihydropyridine-3- carbonitrile; A new scaffold for p38α MAP kinase inhibition
Serry, Aya M.,Luik, Sabine,Laufer, Stefan,Abadi, Ashraf H.
experimental part, p. 559 - 565 (2010/09/05)
Two series of new compounds with the general formula 4,6-diaryl-2-oxo-1,2- dihydropyridine-3-carbonitriles and their isosteric 2-imino derivatives were synthesized by the multicomponent reaction of the appropriate acetophenone, aromatic aldehyde, ammonium acetate, and malononitrile or ethyl cyanoacetate. The products were obtained with excellent yields. The prepared compounds were evaluated for their in vitro ability to inhibit p38 α-MAP kinase. Several compounds showed p38 MAP kinase inhibitory properties with IC50 as low as 0.07 μM. This is the first time to report compounds with such scaffold as p38 α-MAP kinase inhibitors. This asserts the potentiality of multicomponent reactions in drug discovery.
