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N-Cyclohexyl-2-piperazin-1-yl-acetamide (also known as Esaprazole, Hexaprazole, or C 63) is a compound initially recognized for its gastroprotective effects but later identified to exhibit neuroprotective properties and sigma-1 receptor (σ1) binding activity. Studies on its analogues suggest that structural modifications, particularly at the R1 position, can influence metabolic stability and blood-brain barrier penetration, though a definitive structure-activity relationship for neuroprotection remains unclear. These findings highlight its potential as a scaffold for developing neuroprotective agents targeting σ1 receptors.

64204-55-3

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64204-55-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 64204-55-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,2,0 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64204-55:
(7*6)+(6*4)+(5*2)+(4*0)+(3*4)+(2*5)+(1*5)=103
103 % 10 = 3
So 64204-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H23N3O/c16-12(10-15-8-6-13-7-9-15)14-11-4-2-1-3-5-11/h11,13H,1-10H2,(H,14,16)

64204-55-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-cyclohexyl-2-piperazin-1-ylacetamide

1.2 Other means of identification

Product number -
Other names 1-Piperazineacetamide, N-cyclohexyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64204-55-3 SDS

64204-55-3Downstream Products

64204-55-3Relevant academic research and scientific papers

Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters

Barn, David R.,Morphy, J. Richard,Rees, David C.

, p. 3213 - 3216 (2007/10/03)

A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of resin-bound benzylic esters to amides under ambient conditions. The reactions were monitored in 'real-time' using 13C gel phase NMR.

EXPERIMENTAL ANTIULCER AGENTS: N-SUBSTITUTED 2-(4-METHYL-1-PIPERAZINYL)ACETAMIDES AS PIRENZEPINE MODELS AND SOME RELATED COMPOUNDS

Hulinska, Hana,Polivka, Zdenek,Jilek, Jiri,Sindelar, Karel,Holubek, Jiri,et al.

, p. 1820 - 1844 (2007/10/02)

Reactions of N-cyclohexyl-2-chloroacetamide, N-phenyl-2-chloroacetamide, N-(4-dimethylaminophenyl)-2-chloroacetamide, N-(2-nitrophenyl)-N-phenyl-2-chloroacetamide, its 3-nitrophenyl and 4-nitrophenyl analogues, N-(2-benzylphenyl)-2-chloroacetamide, 5-(chloroacetyl)dibenzazepine, and its 10,11-dihydro derivative with piperazine, 1-methylpiperazine, 2-(1-piperazinyl)ethanol, and 3-(1-piperazinyl)propanol resulted in compounds II, III, V -XV, XVIII, XXI, and XXIII, simple analogues of the antiulcer agent pirenzepine (I).Contributions to the syntheses and characterization of mianserin (XIX), bisnor analogue of imipramine (XXV), and pirenzepine (I) are presented.Two 2-aryl-2-(2-pyridyl)thioacetamides XXXVIII and XL were synthesized via nitriles XXXIX and XLI.Compounds XI (VUFB-17 104) and XXI (VUFB-17 113) were found to be rather effective as anti-ulcer agents and anticholinergics.

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