64206-54-8 Usage
Uses
Used in Pharmaceutical Industry:
2-Valeryloxybenzoic acid is used as a selective inhibitor of Cox-1 for its anti-inflammatory and analgesic properties. It specifically targets the cyclooxygenase-1 (Cox-1) enzyme, which plays a crucial role in the production of prostaglandins, responsible for inflammation and pain. By inhibiting Cox-1, 2-valeryloxybenzoic acid can help alleviate these symptoms without affecting Cox-2, another enzyme involved in inflammation, thus potentially reducing the risk of side effects associated with non-selective Cox inhibitors.
Used in Chemical Synthesis:
2-Valeryloxybenzoic acid can be utilized as a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a valuable building block in the development of new compounds with specific applications.
Used in Research and Development:
As a selective Cox-1 inhibitor, 2-valeryloxybenzoic acid is an important tool in the study of the role of Cox enzymes in inflammation, pain, and other physiological processes. Researchers can use 2-VALERYLOXYBENZOIC ACID to investigate the mechanisms of action, develop new drugs with improved selectivity and efficacy, and explore potential therapeutic applications in various disease conditions.
Biological Activity
valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].
references
[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.
Check Digit Verification of cas no
The CAS Registry Mumber 64206-54-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,2,0 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64206-54:
(7*6)+(6*4)+(5*2)+(4*0)+(3*6)+(2*5)+(1*4)=108
108 % 10 = 8
So 64206-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H14O4/c1-2-3-8-11(13)16-10-7-5-4-6-9(10)12(14)15/h4-7H,2-3,8H2,1H3,(H,14,15)
