64207-03-0

Upstream product

• 106-44-5 p-cresol 
• 79-31-2 isobutyric Acid 
• 103-93-5 p-tolyl isobutyrate 

Downstream Products

• 57646-01-2 3,6-dimethyl-4H-chromen-4-one 
• 1045601-30-6 C₁₃H₁₈O₃ 
• 70977-80-9 3-Amino-2-hydroxy-5-methyl-isobutyrophenon 
• 70977-92-3 1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 2-hydroxy-3-isobutyryl-5-methyl-anilide 
• 70977-43-4 1⁽²⁾H-tetrazole-5-carboxylic acid 2-hydroxy-3-isobutyryl-5-methyl-anilide 
• 70978-42-6 2-hydroxy-5-methyl-3-nitro-isobutyrophenone 
• 30574-34-6 1-(2-methoxy-5-methyl phenyl)-2-methyl-propane-1-one 
• 109041-65-8 2-(2-hydroxy-5-methyl-phenyl)-3-methyl-butan-2-ol 

Relevant academic research and scientific papers

C-H Functionalization via Remote Hydride Elimination: Palladium Catalyzed Dehydrogenation of ortho-Acyl Phenols to Flavonoids

Although deprotonation of electron-poor C-H bonds to carbon anions with bases has long been known and widely used in organic synthesis, the hydride elimination from electron-rich C-H bonds to carbon cations or partial carbocations for the introduction of nucleophiles is a comparatively less explored area. Here we report that the carbonyl β-C(sp3)-H bond hydrogens of ortho-acyl phenols could be substituted by intramolecular phenolic hydroxyls to form O-heterocycles, followed by dehydrogenation of the O-heterocycle into flavonoids. The cascade reaction is catalyzed by Pd/C without added oxidants and sacrificing hydrogen acceptors.