642083-40-7

Upstream product

• 165306-22-9 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 109-01-3 1-methyl-piperazine 
• 642083-39-4 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-((4-methylpiperazino)methyl)thymidine 

Relevant academic research and scientific papers

FUNCTIONALIZED NUCLEOTIDE DERIVATIVES

A nucleotide derivative is disclosed, which in its 4’ and/or 5’ position on the sugar moiety is substituted with a group comprising a non-aromatic cyclid group comprising at least one nitrogen atom, said cyclid group optionally being substituted. The nucl

N-methylpiperazinocarbonyl-2',3'-BcNA and 4'-C-(N-methylpiperazino)methyl-DNA: introduction of basic functionalities facing the major groove and the minor groove of a DNA:DNA duplex.

Piperazino-functionalized 2',3'-BcNA and 4'-C-hydroxymethyl-DNA are appropriate molecular architectures for the introduction of basic functionalities facing the major groove and the minor groove of nucleic acid duplexes, respectively. 4'-C-(N-Methylpipera