64228-66-6Relevant academic research and scientific papers
Novel coumarin-containing aminophosphonatesas antitumor agent: synthesis, cytotoxicity, DNA-Binding and apoptosis evaluation
Li, Ya-Jun,Wang, Cai-Yi,Ye, Man-Yi,Yao, Gui-Yang,Wang, Heng-Shan
, p. 14791 - 14809 (2015/09/21)
A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) and human lung adenocarcinoma (MGC-803) cell lines in vit
Coumarin-containing aminophosphonates bridged with chiral side chain: Synthesis and influence of chirality on cytotoxicity and DNA binding
Li, Ya-Jun,Ye, Man-Yi,Huang, Ri-Zhen,Yao, Gui-Yang,Pan, Ying-Ming,Liao, Zhi-Xin,Wang, Heng-Shan
, p. 3144 - 3156 (2014/05/06)
A series of novel coumarin-containing α-Aminophosphonates with two chiral centers were synthesized and a single-crystal structure of compound 8g (8g', (R)-diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(2- bromophenyl)methylphosphonate) was
A Novel Catalytic Three-Component Synthesis (Kabachnick-Fields Reaction) of α-Aminophosphonates from Ketones
Matveeva, Elena D.,Podrugina, Tatyana A.,Tishkovskaya, Elena V.,Tomilova, Larisa G.,Zefirov, Nikolay S.
, p. 2321 - 2324 (2007/10/03)
A novel and highly convenient catalytic variant of the synthesis of α-aminophosphonates on basis of the Kabachnik-Fields reaction [three-component reaction of ketones, diethylphosphite and either benzylamine (series a) of ammonium carbonate (series b)] in the presence of tetra-tert-butylphthalocyanines has been developed. This method affords α-aminophosphonates in acceptable yields for various ketones, including cyclic, sterically hindered and cage ketones. The unsubstituted α-aminophosphonic acids were also obtained from the corresponding esters of series b.
