64230-54-2Relevant academic research and scientific papers
A mild and efficient synthesis of spiroquinolinones via an unexpected rearrangement
Zou, Bin,Leong, Seh Yong,Ding, Mei,Smith, Paul W.
, p. 6016 - 6018 (2015)
A mild and efficient synthesis of spiroquinolinones 6 via condensation of chlorooxoindolines 5 and benzene-1,2-diamines 3 is reported. Instead of expected spirooxindole product 4′, spiroquinolinones 6 were isolated in up to 95% yield. A plausible mechanism involving an interesting ring rearrangement to form spiroquinolinones is proposed.
Synthesis and cytotoxic activity of latentiated derivatives of 3 methyleneoxindole
Kornet,Thio,Thorstenson
, p. 1022 - 1024 (2007/10/08)
Several latentiated derivatives of 3-methyleneoxindole were synthesized and examined for cytotoxic activity. The latentiated forms are represented by three general types which differ in leaving and cleaved groups. All are expected to be converted into 3-methyleneoxindole by bioactivation processes normally occurring in the cell. Two compounds were tested against L-1210 lymphoid leukemia, and six were tested against P-388 lymphocytic leukemia; all were inactive.
