642409-83-4

Upstream product

• 153230-77-4 4,4'-bis(tert-butyldimethylsilyl)-4'-O-demethylepipodophyllol 
• 153230-70-7 4,4'-bis-O-(dimethyl-tert-butylsilyl)-4'-O-demethylepipodophyllotoxin 
• 642409-78-7 2,2-dimethyl-propionic acid 8-(tert-butyl-dimethyl-silanyloxy)-5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-6-ylmethyl ester 
• 642409-81-2 2,2-dimethyl-propionic acid 8-(tert-butyl-dimethyl-silanyloxy)-5-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-7-formyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-6-ylmethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 642409-82-3 5-(tert-butyl-dimethyl-silanyloxy)-8-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-7-(2,2-dimethyl-propionyloxymethyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 

Downstream Products

• 642409-89-0 chloro-acetic acid 6-[9-(4-benzyloxycarbonyloxy-3,5-dimethoxy-phenyl)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yloxy]-8-chloroacetoxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 642409-91-4 Carbonic acid benzyl ester 4-[(5R,5aR,8aS,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-8-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester 
• 642409-85-6 11-oxo-13-deoxo-4'-benzyloxycarbonyl-4'-demethylepipodophyllotoxin 
• 642409-76-5 11-oxo-13-deoxo-4'-demethylepipodophyllotoxin 
• 642409-84-5 5-(tert-butyl-dimethyl-silanyloxy)-9-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-phenyl]-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of retroetoposide

Retro-4′-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4′-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-β-D- glucoside 26 afforded retroetoposide 5 which is