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Usage

Uses

Used in Pharmaceutical Industry:
2,4-Difluorobenzotrifluoride is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with improved properties and therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-Difluorobenzotrifluoride is utilized as an intermediate for the production of agrochemicals, such as pesticides and herbicides. Its presence in these compounds contributes to their effectiveness in controlling pests and weeds, thereby enhancing crop protection and yield.
Used in Organic Synthesis:
2,4-Difluorobenzotrifluoride is employed as a reagent in organic synthesis, facilitating the formation of new organic compounds with desired properties. Its reactivity and stability make it a valuable component in the synthesis of various organic molecules.
Used as a Solvent in Industrial Processes:
In various industrial processes, 2,4-Difluorobenzotrifluoride is used as a solvent due to its ability to dissolve a wide range of substances. Its solvent properties are beneficial in processes that require the dissolution of specific compounds for further reactions or separation techniques.
Safety Precautions:
It is essential to handle 2,4-Difluorobenzotrifluoride with care, as it is flammable and can cause irritation to the skin, eyes, and respiratory system upon contact. Proper safety measures, such as wearing protective gear and working in well-ventilated areas, should be followed to minimize potential hazards. Additionally, appropriate storage conditions, including the use of fire-resistant containers and keeping the chemical away from ignition sources, should be maintained to ensure safety.

Upstream product

• 1583-58-0 2,4-difluoro-benzoic acid 
• 288101-48-4 2-(2,4-difluorophenyl)-4,4, 5,5-tetramethyl-1,3,2-dioxaborolane 
• 1643-19-2 tetrabutylammomium bromide 
• 77152-08-0 trifluoromethylcopper(I) 
• 144025-03-6 2,4-difluorophenylboronic acid 
• 115812-34-5 2,4-difluoro-5-chlorobenzotrifluoride 

Downstream Products

• 1233541-64-4 C₉H₈F₄O 
• 1233541-58-6 C₉H₈F₄O 
• 1048921-49-8 2,6-difluoro-3-(trifluoromethyl)benzoic acid 
• 952233-11-3 (5-Fluoro-2-trifluoromethyl-phenyl)-hydrazine hydrochloride 

Relevant academic research and scientific papers

C(sp2)-CF3Reductive Elimination from Well-Defined Argentate(III) Complexes [nBu4N][Ag(Ar)(CF3)3]

The preparation of a series of well-defined, shelf-stable square planar aryl(tris(trifluoromethyl))argentate(III) complexes [nBu4N]+[Ag(Ar)(CF3)3]- and their C(sp2)-CF3 bond-forming reductive elimination are described. Mechanistic studies of the C(sp2)-CF3 reductive elimination from these complexes, including kinetic studies, effect of temperature and solvent, and DFT calculations, indicate that the C(sp2)-CF3 bond-forming process occurred via a concerted reductive elimination pathway.

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Fluoroform-derived CuCF3 for low-cost, simple, efficient, and safe trifluoromethylation of aryl boronic acids in air

Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF3 in DMF in non-dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented funct

Process for the preparation of benzotrifluorides which are substituted by fluorine and optionally in addition by chlorine

Benzotrifluorides substituted by fluorine and optionally in addition by chlorine, some of which are new, are prepared by hydrogenating benzotrifluorides which are substituted by fluorine and chlorine, in the presence of a catalyst and a hydrogen chloride acceptor.