6425-53-2Relevant academic research and scientific papers
BIS-AMINES, COMPOSITIONS, AND USES RELATED TO CXCR4 INHIBITION
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Page/Page column 65, (2017/02/09)
This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula (I), salts, derivatives, and prodrugs thereof wherein, A is a bridging aryl or heterocyclyl and R1 and R2 are further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.
Symmetrical bis-tertiary amines as novel CXCR4 inhibitors
Bai, Renren,Liang, Zhongxing,Yoon, Younghyoun,Liu, Shuangping,Gaines, Theresa,Oum, Yoonhyeun,Shi, Qi,Mooring, Suazette Reid,Shim, Hyunsuk
, p. 340 - 350 (2016/05/24)
CXCR4 inhibitors are promising agents for the treatment of cancer metastasis and inflammation. A series of novel tertiary amine derivatives targeting CXCR4 were designed, synthesized, and evaluated. The central benzene ring linker and side chains were mod
Synthesis of novel aromatic core zero generation dendrimers
Füst?s, Melinda-Emese,Sipos, Tmea-Anita,Diudea, Mircea V.,Katona, Gabriel
, p. 129 - 132 (2015/08/06)
Bromomethyl arenes used as polyfunctional core of dendrimers were derivatized with diethanolamine branches. The obtained compounds containing 4 or 6 hydroxyl terminal surface groups are highly water-soluble.
A fast and highly efficient method for the synthesis of tertiary amines in aqueous medium
Adimurthy, Subbarayappa,Joshi, Girdhar
experimental part, p. 771 - 775 (2011/01/04)
A facile and highly efficient method for the synthesis of tertiary amines by the reaction of secondary amines with benzylic bromides and 1,1'-dibromo p/o-xylenes in aqueous dioxane and NaOH is described. The reactions are dually promoted by the base in short time (15 min.) at ambient conditions in aqueous medium.
