6427-21-0 Usage
Uses
Used in Chemical Synthesis:
ISOCYANATO(METHOXY)METHANE is used as a building block for the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. Its reactivity and versatility make it a valuable intermediate in the production of a wide range of molecules.
Used in Polymer Industry:
In the polymer industry, ISOCYANATO(METHOXY)METHANE is used as a monomer for the production of polyurethanes and other polymeric materials. Its ability to form stable linkages with other monomers contributes to the development of materials with specific properties, such as flexibility, durability, and resistance to various environmental factors.
Used in Coatings and Adhesives:
ISOCYANATO(METHOXY)METHANE is used as a component in the formulation of coatings and adhesives, providing enhanced bonding and improved performance characteristics. Its ability to form strong cross-links with other components in the formulation contributes to the development of high-quality products with increased durability and resistance to wear and tear.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ISOCYANATO(METHOXY)METHANE is used as a key intermediate in the synthesis of various drugs and drug candidates. Its unique reactivity allows for the development of novel therapeutic agents with improved efficacy and reduced side effects.
Used in Research and Development:
ISOCYANATO(METHOXY)METHANE is also utilized in research and development settings, where it serves as a valuable tool for the synthesis and modification of complex organic molecules. Its versatility and reactivity make it an essential component in the development of new materials and compounds with potential applications in various industries.
Air & Water Reactions
Highly flammable. Soluble in water.
Reactivity Profile
Isocyanates and thioisocyanates, such as ISOCYANATO(METHOXY)METHANE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Check Digit Verification of cas no
The CAS Registry Mumber 6427-21-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,2 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 6427-21:
(6*6)+(5*4)+(4*2)+(3*7)+(2*2)+(1*1)=90
90 % 10 = 0
So 6427-21-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO2/c1-6-3-4-2-5/h3H2,1H3
6427-21-0Relevant articles and documents
Alkylation of Nitrocyanamide. A New Synthesis of Isocyanates
Boyer, Joseph H.,Manimaran, Thanikavelu,Wolford, Lionel T.
, p. 2137 - 2140 (2007/10/02)
Thirteen alkyl halides (primary, secondary, and tertiary aliphatic including alicyclic, aralkyl, and heteroalkyl systems) and certain non-vicinal dihalides on treatment with silver nitrocyanamide are converted into the corresponding isocyanates (63-95percent).Intermediate alkylnitrocyanamides, spectroscopically detected, thermolysed (-20-80 deg C) to the expected isocyanates.In certain examples silver nitrocyanamide is generated in situ from sodium nitrocyanamide and silver nitrate.Silver nitrocyanamide does not react with cyclopropyl bromide, acetyl chloride, toluene-p-sulphonyl chloride, phenacyl bromide and 2-bromomethyldioxolane (27), and the ethylene acetal (28) of 1-bromo-4-iodopentacyclo-nonan-9-one.Silver nitrocyanamide reacts with 4,6-bis(bromomethyl)-3,7-dimethyl-1,5-diazabicyclo3.3.0)octane-2,8-dione (26), to give an intractable mixture.Vicinal dihalides give erratic results without detectable formation of vicinal di-isocyanates: unisolated 2-bromoethyl isocyanate (tentative assignment) has been detected in a product mixture from ethylene dibromide; an expected rearrangement during the reaction with 1,2-dibromocyclobutane, brought about the formation of 4-bromobut-3-enyl isocyanate isolated as ethyl 4-bromobut-3-enylcarbamate in low yield; and 1,2-dibromocyclohexane gives 2-bromocyclohexyl isocyanate isolated as ethyl N-(2-bromocyclohexyl)-carbamate in low yield.
Process for the preparation of alkoxymethyl-isocyanates
-
, (2008/06/13)
This disclosure relates to a process for the preparation of alkoxymethylisocyanates by reacting alkoxylmethyl tri-substituted ureas with isocyanates which have higher boiling points than the alkoxy methyl isocyanates produced. The process is also applicable to alkenoxy methyl tri-substituted ureas to make the corresponding isocyanates. Ureas of commercial purity may be used to obtain good yields of isocyanate when between about 0.03 and 0.2 mol of carbodiimide groups are present per mol of urea group. The carbodiimide containing compounds may also carry free isocyanate groups, in which case they should have a boiling point above that of the isocyanate product.
