64298-15-3

Upstream product

• 64298-09-5 Acetic acid 2-(1-acetoxymethyl-vinyl)-5-methyl-phenyl ester 
• 64298-14-2 2-(2'-Acetoxy-4'-methylphenyl)-prop-2-enal 
• 61955-73-5 2-(2-acetoxy-4-methylphenyl)propene 

Downstream Products

• 62487-24-5 3,10-diisobutyryloxy-8,9-dehydrothymol 

Relevant academic research and scientific papers

Synthesis of Two Naturally Ocurring Isobutyrates Related to Thymol

7-Acetoxymethylcoumarin (15), prepared by heating 7-bromomethyl-4-methylcoumarin (14) with sodium acetate and acetic acid, on heating with NaOH-ethylene glycol, furnishes 3-hydroxy-4-isopropylbenzyl alcohol (3).Compound (3) has been transformed into diisobutyrate (1) of 3-hydroxy-4-isopropylbenzyl alcohol.Selective methylation of 3 furnishes 4-isopropyl-3-methoxybenzyl alcohol (5), an intermediate for the synthesis of sempervirol.Acylation of 5 gives the naturally ocurring 4-isopropyl-3-methoxybenzyl isobutyrate (2). 4,7-Dimethylcoumarin affords o-isopropenylphenol (7) when heated with aq.NaOH at 140 deg C, but if the reaction is carried out at 210 deg C the product formed is m-cresol (17).