61955-73-5Relevant academic research and scientific papers
Total Synthesis of a Dimeric Thymol Derivative Isolated from Arnica sachalinensis
De Silvestro, Irene,Drew, Samuel L.,Nichol, Gary S.,Duarte, Fernanda,Lawrence, Andrew L.
supporting information, p. 6813 - 6817 (2017/06/06)
The total synthesis of a dimeric thymol derivative (thymarnicol) isolated from Arnica sachalinensis was accomplished in 6 steps. A key biomimetic Diels–Alder dimerization was found to occur at ambient temperature and the final oxidative cyclization occurs
Synthesis of Two Naturally Ocurring Isobutyrates Related to Thymol
Sanghvi, Y. S.,Rao, A. S.
, p. 952 - 954 (2007/10/02)
7-Acetoxymethylcoumarin (15), prepared by heating 7-bromomethyl-4-methylcoumarin (14) with sodium acetate and acetic acid, on heating with NaOH-ethylene glycol, furnishes 3-hydroxy-4-isopropylbenzyl alcohol (3).Compound (3) has been transformed into diisobutyrate (1) of 3-hydroxy-4-isopropylbenzyl alcohol.Selective methylation of 3 furnishes 4-isopropyl-3-methoxybenzyl alcohol (5), an intermediate for the synthesis of sempervirol.Acylation of 5 gives the naturally ocurring 4-isopropyl-3-methoxybenzyl isobutyrate (2). 4,7-Dimethylcoumarin affords o-isopropenylphenol (7) when heated with aq.NaOH at 140 deg C, but if the reaction is carried out at 210 deg C the product formed is m-cresol (17).
