64299-06-5Relevant articles and documents
Synthesis and biological evaluation of a γ-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24- octahydrocyclododeca[1,2-b:4,5-b':7,8-b :10,11-b ']tetraindole (CTet)
Lucarini, Simone,De Santi, Mauro,Antonietti, Francesca,Brandi, Giorgio,Diamantini, Giuseppe,Fraternale, Alessandra,Paoletti, Maria Filomena,Tontini, Andrea,Magnani, Mauro,Duranti, Andrea
, p. 4085 - 4093 (2010)
5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b':7,8-b :10, 11-b ']tetrai ndole (CTet), an indole-3-carbinol (I3C) metabolite endowed with anticancer properties, is poorly soluble in the solvents most frequently used in biological tests. This study indicates that the use of γ-cyclodextrin (γ-CD) avoids this problem. Formulated with γ-CD CTet is a potent inhibitor of DNA synthesis in both estrogen receptor positive (MCF-7) and estrogen receptor negative (MDA-MB-231) human breast cell lines (IC50 = 1.20 ± 0.04 μM and 1.0 ± 0.1 μM, respectively).
Convenient synthesis of 5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b′:7,8-b″] triindole, a Novel phytoestrogen
Staub, Richard E.,Bjeldanes, Leonard F.
, p. 167 - 169 (2007/10/03)
An efficient one-pot synthesis is described of 5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b':7,8-b ]triindole (CTr), a potent estrogen agonist from food plants. For the procedure, gramine is treated with dimethyl sulfate and sodium in ethanol at room temperature. Quenching of the reaction with water and workup of the product provides CTr in approximately 75% yield.