74028-19-6Relevant articles and documents
A practical and expeditious method for the preparation of the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b′: 7,8-b″:10,11-b?]tetraindole (CTet)
Lucarini, Simone,Antonietti, Francesca,Tontini, Andrea,Mestichelli, Paola,Magnani, Mauro,Duranti, Andrea
, p. 2812 - 2814 (2011)
A new synthetic method to obtain the potential anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b′:7, 8-b′′:10,11-b′′′]tetraindole (CTet), starting from 1H-indole-3-carboxaldehyde and sulfamide, is described. Although a mixture of CTet and cyclic indole trimer (CTr) is formed, higher CTet/CTr ratio (4:6) and CTet yield (15%) make our protocol more favorable than those reported in the literature. A discussion on the possible reaction mechanism is reported.