64301-00-4Relevant academic research and scientific papers
2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents
Novinson,Springer,O'Brien,Scholten,Miller,Robins
, p. 420 - 426 (2007/10/02)
A series of new 2-(alkylthio)-5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines have been prepared as inhibitors of cAMP phosphodiesterase from various tissues. These derivatives were prepared via ring closure of various requisite 3-amino-1,2,4-triazole
2-SUBSTITUTED-S-TRIAZOLO[1,5A]-PYRIMIDINES
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, (2008/06/13)
2-Substituted-s-triazolo[1,5a]pyrimidines are disclosed which are useful as inhibitors of phosphodiesterase enzymes or intermediates in the production process. Such comoounds are of the following structure: wherein X, R, R1, R2 and R3 are as defined herei
