14090-88-1

Basic information

• Product Name: NONANE-4,6-DIONE
• Synonyms: NONANE-4,6-DIONE;AKOS MSC-0382;4,6-Nonanedione;4,6-Nonanedione,99%;Nonane-4,6-dione ,99%
• CAS NO: 14090-88-1
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22
• EINECS: 237-938-7
• Mol File: 14090-88-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 79-81°C 8mm
• Flash Point: 81.1 °C
• Appearance: /
• Density: 0.911 g/cm³
• Vapor Pressure: 0.0921mmHg at 25°C
• Refractive Index: 1.424
• CAS DataBase Reference: NONANE-4,6-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: NONANE-4,6-DIONE(14090-88-1)
• EPA Substance Registry System: NONANE-4,6-DIONE(14090-88-1)

Safety Data

• Hazardous Substances Data: 14090-88-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A nonanone carrying oxo substituents at positions 4 and 6 respectively.

InChI:InChI=1/C9H16O2/c1-3-5-8(10)7-9(11)6-4-2/h3-7H2,1-2H3

Upstream product

• 109-21-7 butyl butyrate 
• 107-87-9 2-Pentanone 
• 105-54-4 butanoic acid ethyl ester 
• 106-31-0 butanoic acid anhydride 
• 105-53-3 diethyl malonate 
• 1197-40-6 2,2'-difurylmethane 
• 52762-53-5 6-hydroxy-nonan-4-one 
• 141-75-3 butyryl chloride 
• 84219-62-5 4,6-nonanediol 
• 927-77-5 n-propylmagnesium bromide 
• 1663-67-8 malonoyl dichloride 
• 62763-37-5 butyric O-ethyl-carbonic anhydride 
• 107-92-6 butyric acid 
• 108-05-4 vinyl acetate 

Downstream Products

• 92887-75-7 4,6-Dipropyl-2-(4-toluidino)pyrimidin 
• 64301-00-4 2-benzylsulfanyl-5,7-dipropyl-[1,2,4]triazolo[1,5-a]pyrimidine 
• 87253-54-1 5,7-di-n-propyl-2-p-fluorobenzylamino-s-triazolo<1,5-a>pyrimidine 
• 107-87-9 2-Pentanone 
• 107-92-6 butyric acid 
• 1443156-91-9 (R)-5-butyryl-4-phenyl-6-propyl-3,4-dihydro-2H-pyran-2-one 
• 1380241-17-7 C₁₆H₁₈Cl₂N₂O₂ 
• 1380241-15-5 C₁₆H₁₉BrN₂O₂ 
• 1232578-65-2 ethyl 4-(2-oxopentyl)benzoate 
• 52708-03-9 (S)-4-nonanol 
• 36685-04-8 4,6-Bis-(2-carboxybenzoyloxy)nonan 
• 36685-05-9 phthalic acid 1,1'-((S,S)-1,3-dipropyl-propane-1,3-diyl) ester 

Relevant articles and documents

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Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure-Activity Relationships

Acid ceramidase (AC) is a lysosomal cysteine amidase responsible for the cleavage of ceramide into sphingosine, which is then phosphorylated to sphingosine 1-phosphate. AC regulates the intracellular levels of ceramide and sphingosine, and AC inhibition may be useful in the treatment of disorders, such as cancer, in which ceramide-mediated signaling may be dysfunctional. Despite their potential experimental and therapeutic value, the number of available small-molecule inhibitors of AC activity remains limited. In the present study is described the discovery of a class of potent pyrazole carboxamide-based AC inhibitors, which were identified using the atomic property field (APF) approach and developed through systematic SAR investigations and in vitro pharmacological characterization. The best compound of this series inhibits AC with nanomolar potency and causes ceramide accumulation and sphingosine depletion in intact G361 proliferative melanoma cells. By expanding the current armamentarium of AC inhibitors, these results should facilitate future efforts to unravel the biology of AC and the therapeutic potential of its inhibition.

PROCESSES FOR PREPARING β-DIKETONE COMPOUND, METAL COMPLEX THEREOF AND METALLIC COMPOUND

Disclosed is a process for preparing a β-diketone compound such as 2,6-dimethyl-3,5-heptanedione, which comprises reacting an ester compound such as an alkyl isobutyrate with a ketone compound such as 3-methylbutanone in the presence of an alkali metal alkoxide as a catalyst. The process comprises a step 1 in which an ester compound CR1R2R3COOQ is reacted with a ketone compound CR4R5R6COCH2R7 using an alkali metal alkoxide catalyst to give a β-diketone compound CR1R2R3COCHR4R5R6. (In the formulae, R7 is hydrogen or an alkyl group of 1 to 4 carbon atoms while others are each independently hydrogen or an alkyl group of 1 to 3 carbon atoms, and at least one of R1 to R6 is hydrogen.)

Asymmetric hydrogenation method of a ketonic compound and derivative

The present invention relates to a process for the asymmetric hydrogenation of a ketonic compound and derivative. The invention relates to the use of optically active metal complexes as catalysts for the asymmetric hydrogenation of a ketonic compound and derivative. The process for the asymmetric hydrogenation of a ketonic compound and derivative is characterized in that the asymmetric hydrogenation of said compound is carried out in the presence of an effective amount of a metal complex comprising as ligand an optically active diphosphine corresponding to one of the following formulae: STR1