643036-49-1

Upstream product

• 63930-49-4 (R)-3-(benzyloxy)-2-methylpropan-1-ol 
• 203454-44-8 (R)-4-Benzyl-3-((S)-3-benzyloxy-2-methyl-propionyl)-oxazolidin-2-one 
• 3587-60-8 Benzyloxymethyl chloride 
• 72297-80-4 1-[((S)-3-iodo-2-methylpropoxy)methyl]benzene 
• 192060-67-6 (1R,2R)-(-)-pseudoephedrinepropionamide 

Downstream Products

• 922523-28-2 C₁₅H₂₂O₂ 
• 922523-33-9 C₃₃H₄₁NO₆ 
• 922523-29-3 C₁₉H₃₂OSi 
• 922523-50-0 C₁₆H₂₁O₄SF₃ 
• 157810-31-6 (2S,4R)-5-(benzyloxy)-2,4-dimethylpentan-1-ol 

Relevant academic research and scientific papers

Synthesis of the southern FGHI ring system of azaspiracid-1 and investigation into the controlling elements of C28- and C36-ketalization

Heading south: An efficient approach to the FGHI southern ring system of azaspiracid-1 is disclosed. Each of the eight stereogenic centers is generated with excellent diastereoselectivity. In addition, the stereochemical outcome of the ketalization steps could be controlled by careful selection of the conditions. Teoc = 2-(trimethylsilyl)ethoxycarbonyl; TMS = trimethylsilyl; TIPS = triisopropylsilyl; Bn = benzyl. (Chemical Equation Presented).

Synthetic routes to the stereoisomers of 2,4-dimethylpentane-1,5-diol derivatives

Five different routes to every stereoisomer of non-symmetric derivatives of 2,4-dimethylpentanedioic acid and/or of O-monoprotected 2,4-dimethylpentane- 1,5-diols, which are common building blocks for the total synthesis of many polypropionates, have been investigated. Alkylation of the lithium enolate of N-propanoylpseudoephedrine turned out to be the most appropriate method, in connection with the synthesis of fragment C1-C5 of amphidinolide K.