6431-73-8

Basic information

• Product Name: 2H-1,4-Benzothiazin-3(4H)-one, 4-(phenylmethyl)-
• CAS NO: 6431-73-8
• Molecular Formula: C15H13NOS
• Molecular Weight: 255.34
• Mol File: 6431-73-8.mol

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzothiazin-3(4H)-one, 4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzothiazin-3(4H)-one, 4-(phenylmethyl)-(6431-73-8)
• EPA Substance Registry System: 2H-1,4-Benzothiazin-3(4H)-one, 4-(phenylmethyl)-(6431-73-8)

Safety Data

• Hazardous Substances Data: 6431-73-8(Hazardous Substances Data)

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 1239573-83-1 N-benzyl-2-chloro-N-(2-bromophenyl)acetamide 
• 1239573-73-9 N-benzyl-2-chloro-N-(2-iodophenyl)-acetamide 
• 5325-20-2 2H-1,4-benzothiazin-3-one 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 158427-46-4 2-[[3-(Bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl]-α-hydroxy-methyl]-4-(phenylmethyl)-2H-1,4-benzothiazin-3(4H)-one 
• 745073-81-8 N-benzyl-2-(dicarbomethoxyethyl)-1,4-benzothiazin-3-one 
• 6397-14-4 4-benzyl-3,4-dihydro-2H-benzo[1,4]thiazine 

Relevant articles and documents

Synthesis of Chiral 2-Substituted 1,4-Benzoxazin-3-ones via Iridium-Catalyzed Enantioselective Hydrogenation of Benzoxazinones

An efficient iridium-catalyzed enantioselective hydrogenation of 2-alkylidene 1,4-benzoxazin-3-ones using our developed iPr-BiphPHOX as a ligand is reported. This method showed good functional group compatibility and delivered the corresponding reduced products in excellent yields (up to 99%) with excellent enantioselectivities (up to 99% ee). The reaction proceeded very well on a gram scale with low catalyst loadings (0.1 mol %), providing the product with no erosion in enantioselectivity. Additionally, three bioactive molecules can be easily obtained from the reduced products.

gSK - 3 beta inhibitor or its salt and its pharmaceutical use

The invention belongs to the pharmaceutical chemistry field, and discloses a compound for inhibiting glycogen synthase kinase-3beta (GSK-3beta) in a formula I, its pharmaceutically acceptable salt, or an application of its pharmaceutical composition for preventing and treating the GSK-3beta-related diseases. The compound is a GSK-3beta small-molecule inhibitor, its action mode is non-ATP-competitive competition, and can be used for preparing the medicines for preventing and treating the GSK-3beta-related diseases, and the GSK-3beta-related diseases can be diabetes, Alzheimer's disease, stomach cancer, colorectal cancer, pancreas cancer, liver cancer or mixed acute leukemia. According to the compound, R1, R2, R3, X, Y are consistent with detailed description in the invention.

Copper-catalyzed cascade syntheses of 2 H -benzo[ b ][1,4]thiazin-3(4 H)-ones and quinoxalin-2(1 H)-ones through capturing S and N atom respectively from AcSH and TsNH2

A copper-catalyzed cascade method has been developed to synthesize the 2H-benzo[b][1,4]thiazin-3(4H)-ones from 2-halo-N-(2-halophenyl)-acetamides 1 and AcSH via the SN2/deacetylation/coupling process, and to synthesize the quinoxalin-2(1H)-ones from 1 and TsNH2 via the S N2/coupling/desulfonation process. The target products were obtained with diversity at three positions on their scaffolds.

Michael additions on 2H-1,4-benzothiazin-3-ones

Michael addition on 2H-1,4-benzothiazin-3-ones is studied in this communication. An approach towards the regioselective synthesis of Michael adducts is shown.

An Improved Alkylation of 2H-1,4-Benzothiazin-3(4H)-one and Related Heterocyclic Anilides

Various N-substituted derivatives of 2H-1,4-benzothiazin-3(4H)-one are obtained in high yields employing functionalized alkyl halides and potassium tert-butoxide in dimethylformamide.The method is mild, regioselective and tolerates a variety of functional groups.