64318-08-7

Basic information

• Product Name: 4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE
• Synonyms: 4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE
• CAS NO: 64318-08-7
• Molecular Formula: C₁₀H₆Cl₂O₂S
• Molecular Weight: 261.12
• Mol File: 64318-08-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 360.1°Cat760mmHg
• Flash Point: 171.6°C
• Appearance: /
• Density: 1.516g/cm³
• Vapor Pressure: 4.71E-05mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE(64318-08-7)
• EPA Substance Registry System: 4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE(64318-08-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 64318-08-7(Hazardous Substances Data)

Usage

Description

4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE is a chemical compound with the molecular formula C10H6Cl2O2S. It is an organosulfur compound that is commonly used as a reagent in organic synthesis. This chemical is a white to off-white crystalline solid that is soluble in organic solvents such as dichloromethane and acetone. Its reactivity and ability to form strong covalent bonds make it a valuable building block in organic chemistry.

Uses

Used in Pharmaceutical Industry:
4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE is used as a precursor in the synthesis of pharmaceuticals for its reactivity and ability to form strong covalent bonds, making it a valuable building block in the development of various medicinal compounds.
Used in Dye Industry:
4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE is used as a precursor in the synthesis of dyes due to its reactivity and ability to form strong covalent bonds, contributing to the creation of a wide range of colorants for various applications.
Used in Organic Synthesis:
4-CHLORO-NAPHTHALENE-1-SULFONYL CHLORIDE is used as a reagent in organic synthesis for its reactivity and ability to form strong covalent bonds, making it a valuable building block in the creation of various organic compounds.
It is important to handle and use this chemical with caution, as it can be harmful if inhaled, swallowed, or in contact with skin.

InChI:InChI=1/C10H6Cl2O2S/c11-9-5-6-10(15(12,13)14)8-4-2-1-3-7(8)9/h1-6H

Upstream product

• 90-13-1 1-Chloronaphthalene 
• 6328-72-9 4-chloro-1-naphthylsulphonic acid 

Downstream Products

• 1089187-48-3 4-chloro-1-naphthalenesulfonyl-N-{2,3-dihydro-2,2-dimethyl-7-{2-[4-(2-methoxy-5-trifluoromethyl-phenyl)-piperazine]-ethoxy}-benzofuran-5-yl}-amide hydrochloride 
• 1825-31-6 1,4-dichloronaphthalene 
• 6328-72-9 4-chloro-1-naphthylsulphonic acid 
• 6334-37-8 1-chloro-4-iodo-naphthalene 

Relevant articles and documents

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4

Fatty acid binding protein 4 (FABP4) plays a critical role in metabolism and inflammatory processes and therefore is a potential therapeutic target for immunometabolic diseases such as diabetes and atherosclerosis. Herein, we reported the identification of naphthalene-1-sulfonamide derivatives as novel, potent and selective FABP4 inhibitors by applying a structure-based design strategy. The binding affinities of compounds 16dk, 16do and 16du to FABP4, at the molecular level, are equivalent to or even better than that of BMS309403. The X-ray crystallography complemented by the isothermal titration calorimetry studies revealed the binding mode of this series of inhibitors and the pivotal network of ordered water molecules in the binding pocket of FABP4. Moreover, compounds 16dk and 16do showed good metabolic stabilities in liver microsomes. Further extensive in vivo study demonstrated that 16dk and 16do exhibited a dramatic improvement in glucose and lipid metabolism, by decreasing fasting blood glucose and serum lipid levels, enhancing insulin sensitivity, and ameliorating hepatic steatosis in obese diabetic (db/db) mice.

Substituted Disulfonamide Compounds

Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).