6432-79-7

Basic information

• Product Name: Propanedioic acid, [(3-methylphenyl)methyl]-, diethyl ester
• Synonyms: (3-Methyl-benzyl)-malonsaeure-diaethylester;m-Methylbenzyl-malonsaeure-diethylester;2-(3-methylbenzyl)malonic acid diethyl ester;(3-methyl-benzyl)-malonic acid diethyl ester
• CAS NO: 6432-79-7
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Mol File: 6432-79-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [(3-methylphenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [(3-methylphenyl)methyl]-, diethyl ester(6432-79-7)
• EPA Substance Registry System: Propanedioic acid, [(3-methylphenyl)methyl]-, diethyl ester(6432-79-7)

Safety Data

• Hazardous Substances Data: 6432-79-7(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 105-53-3 diethyl malonate 
• 95-47-6 o-xylene 
• 620-19-9 1-chloromethyl-3-methyl-benzene 

Relevant articles and documents

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and β-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues. Compound 17 has been taken into phase I clinical trials.

Synthesis of Substituted Tetrahydronaphthalenes by Mn(III), Ce(IV), and Fe(III) Oxidation of Substituted Diethyl α-Benzylmalonates in the Presence of Olefins

The oxidation of substituted diethyl α-benzylmalonates (1a-m) by manganese(III) acetate in acetic acid, cerium(IV) ammonium nitrate in methanol, or iron(III) perchlorate in acetonitrile in the presence of substituted olefins 2a-u was investigated.The results are consistent with a common mechanism.It involves selective generation of malonyl radicals from high-valent metal malonyl complexes, their addition to the olefin, and competition of the adduct radical between intramolecular cyclization to produce highly functionalized tetrahydronaphthalenes (3) and oxidation bymetal salt to give mainly γ-lactones (5).Several electron-withdrawing and releasing substituents on the aromatic ring and on the olefin can be successfully used in the synthesis of 3 without olefin telomerization.The influence of metal and olefin or aromatic substituents on the homolytic addition and intramolecular aromatic substitution is discussed.