64341-49-7

Basic information

• Product Name: 1-BROMO-3-BUTEN-2-OL
• Synonyms: 1-BROMO-3-BUTEN-2-OL;2-(2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-methylphenoxy)acetic acid;1-Bromobut-3-en-2-ol
• CAS NO: 64341-49-7
• Molecular Formula: C₄H₇BrO
• Molecular Weight: 151
• Mol File: 64341-49-7.mol

Chemical Properties

• Boiling Point: 161-162.5℃
• Flash Point: 80.2 °C
• Appearance: /
• Density: 1.499 g/cm³
• Vapor Pressure: 0.341mmHg at 25°C
• Refractive Index: 1.5022 (589.3 nm 15℃)
• CAS DataBase Reference: 1-BROMO-3-BUTEN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-3-BUTEN-2-OL(64341-49-7)
• EPA Substance Registry System: 1-BROMO-3-BUTEN-2-OL(64341-49-7)

Safety Data

• Hazardous Substances Data: 64341-49-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-BROMO-3-BUTEN-2-OL is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to undergo multiple chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1-BROMO-3-BUTEN-2-OL is utilized as a precursor in the production of agrochemicals, specifically in the creation of pesticides and other crop protection agents, due to its reactivity and capacity to form different chemical derivatives.
Used in Fine Chemicals Industry:
1-BROMO-3-BUTEN-2-OL is employed as an intermediate in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and other specialty products.
Used in Organic Synthesis:
1-BROMO-3-BUTEN-2-OL is used as a reagent in organic synthesis for its ability to participate in a wide range of chemical reactions, leading to the formation of diverse organic compounds and derivatives.
Safety Precautions:
It is crucial to handle 1-BROMO-3-BUTEN-2-OL with care, as it is flammable and can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Proper safety measures should be taken to minimize risks during its use and storage.

InChI:InChI=1/C4H7BrO/c1-2-4(6)3-5/h2,4,6H,1,3H2

Upstream product

• 106-99-0 buta-1,3-diene 
• 79-15-2 N-bromoacetamide 
• 7732-18-5 water 
• 155622-69-8 bromomethyl vinyl ketone 

Downstream Products

• 85771-10-4 1-propylamino-but-3-en-2-ol 
• 87088-69-5 2-Propylamino-but-3-en-1-ol 

Relevant articles and documents

Investigation of 1-bromo-3-buten-2-one as building block in organic synthesis

1-Bromo-3-buten-2-one is investigated as a building block for organic synthesis. Reduction to the corresponding alcohol works best with lithium aluminium hydride, reaction with primary amines gives 5-membered-aza-heterocycles in moderate yields and reaction with activated methylene compounds to form 5-membered-carbocycles gave unsatisfactory yields when a one-pot-procedure was used. The first step of a stepwise protocol, a Michael addition, is discussed.

A New Synthetic Method of Preparing Iodohydrin and Bromohydrin Derivatives through in Situ Generation of Hypohalous Acids from H5IO6 and NaBrO3 in the Presence of NaHSO3

Hypohydrous acids such as hypoiodous acid (IOH) and hypobromous acid (BrOH) were found to be easily generated from H5IO6 and NaBrO3 in the presence of an appropriate reducing agent such as NaHSO3.Iodohydrin and bromohydrin derivatives were synthesized in good yields from the reaction of a wide variety of organic compounds bearing carbon-carbon double bonds, with H5IO6 or NaBrO3 and NaHSO3.The iodohydroxylation of internal alkenes was achieved with high stereoselectivity to give anti products, although no stereoselectivity was observed in the bromohydroxylation of these alkenes.It was found that allylic alcohols undergo iodohydroxylation in anti-Markovnikov fashion to form iodo diols in good yields.Treatment of alkynes with H5IO6 combined with NaHSO3 afforded the corresponding ketones in fair yields, but the same treatment with NaBrO3 rather than H5IO6 produced the corresponding α,α-dibromo ketones along with small amounts of the dibromoalkenes.

Total Synthesis of &β-Lactamase Inhibitors based on the 4-Oxa-1-azabicycloheptan-7-one Ring System

4-(2-Bromoethoxy)azetidin-2-one (4), 4-(1,3-dibromoisopropoxy)azetidin-2-one (5), 4-(1-benzyloxy-3-chloroisopropoxy)azetidin-2-one (6), 4-azetidin-2-one (7), and 4-azetidin-2-one (8) have been s