6436-31-3Relevant academic research and scientific papers
Domino 1,4- And 1,6-Addition Reactions of Ketene Silyl Acetals to Dialkynyl Imines Promoted by Aluminum Chloride: Synthesis of Multifunctionalized β-Lactams
Hachiya, Iwao,Nakamura, Kenta,Hara, Masaya,Sato, Koki,Shimizu, Makoto
, p. 14770 - 14794 (2019)
Domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines are disclosed. Aluminum chloride promoted domino 1,4- and 1,6-addition reactions of ketene silyl acetals to dialkynyl imines to give a variety of alkenyl iminocyclobutenones in moderate to good yields. The chemoselective reduction of alkenyl iminocyclobutenones and the subsequent thermal rearrangement of resulting alkenyl aminocyclobutenones in the presence of appropriate amines provided cis or trans multifunctionalized β-lactams in moderate to high yields with good to high diastereoselectivities.
Catalytic hydrogenation of α-iminophosphonates as a method for the synthesis of racemic and optically active α-aminophosphonates
Goulioukina, Nataliya S.,Bondarenko, Grigorii N.,Lyubimov, Sergey E.,Davankov, Vadim A.,Gavrilov, Konstantin N.,Beletskaya, Irina P.
experimental part, p. 482 - 492 (2009/04/10)
It was shown that the catalytic hydrogenation of α-iminophosphonates by molecular hydrogen can serve as a convenient method for the synthesis of racemic and optically active α-aminophosphonates. Up to 94% ee was achieved in the rhodium-catalyzed enantiose
