6437-49-6

Usage

Uses

2-Phenoxypropylamine is used as pharmaceutical intermediate.

InChI:InChI=1/C9H13NO/c1-8(7-10)11-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3

Upstream product

• 6437-44-1 2-phenoxypropionitrile 
• 1252084-55-1 2-[2-phenoxypropyl]-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 15500-82-0 (2-phenoxy-propyl)-(7⁽⁹⁾H-purin-6-yl)-amine 
• 71259-61-5 (7-chloro-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-(2-phenoxy-propyl)-amine 
• 55154-90-0 4-chlorophenylethanamidine 
• 6437-65-6 N-(2-phenoxypropyl) phenylacetamide 
• 6437-54-3 N-(2-phenoxy-propyl)-4-chlorophenylacetamidine p-toluenesulphonate 
• 6437-56-5 N-(2-phenoxypropyl)phenylacetamidine p-toluenesulphonate 
• 68157-87-9 N-(2-phenoxypropyl)acetamide 

Relevant academic research and scientific papers

Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors

A series of phenoxyalkyl and phenylthioalkyl amides were prepared as melatoninergic ligands. Modulation of affinity of the newly synthesized compound by applying SARs around the terminal amide moiety, the alkyl chain, and the methoxy group on the aromatic ring provides compounds with nanomolar affinity for both melatonin receptor subtypes. Affinity towards MT1 and MT2 receptors were modulated also exploiting chirality. The investigation of intrinsic activity revealed that all the tested compounds behave as full or partial agonists.

Serotonin antagonists

A compound of the formula EQU1 or an acid addition salt thereof wherein R1 and R2 are the same or different and each is a phenyl or thien-2-yl group optionally substituted in one or more positions by a substituent selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy), each of the said phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy) substituent groups being optionally substituted in one or more positions by a member selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, and lower alkylthio; A1 is a divalent straight or branched alkylene group containing from two to six carbon atoms and one or two divalent atoms which are each an oxygen or sulphur atom, provided that there are at least two carbon atoms between the divalent atom and the --NH-- group and between the two divalent atoms; and A2 is the methylene group --CH2 --.