64370-35-0Relevant articles and documents
Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates
Ritson, Dougal J.,Cox, Russell J.,Berge, John
, p. 1921 - 1933 (2007/10/03)
An indium mediated procedure has been developed for the allylation of activated O-functionalised oximes and nitriles as exemplified by a variety of glyoxylate derivatives. This method gives the corresponding free (or protected) amine in a one pot-process. The method is regiospecific and is carried out under remarkably mild conditions so that even oxime esters can be subjected to the typical reaction conditions.
Syntheses based on 1,2-secopenicillins. Part 5. Penicillin analogues with electron-withdrawing 2-substituents
Brain, Edward G.,Eglington, A. John,Nayler, John H. C.,Osborne, Neal F.,Southgate, Robert,Tolliday, Patricia
, p. 2479 - 2487 (2007/10/05)
6-Acylaminopenam-3-carboxylic esters substituted at C-2 by one or two alkoxycarbonyl groups or by an acetyl group have been prepared from penicillins. The azetidinone ring remained intact throughout the reaction sequence, and the thiazolidine ring was completed by intramolecular alkylation at an activated methylene or methine group adjacent to the sulphur atom. Only in the case of the 2-alkoxycarbonylpenams could stable carboxylic acids be liberated from the esters.