643744-97-2

Upstream product

• 380241-58-7 4-amino-2-chloro-5-iodobenzonitrile 
• 869214-90-4 (5-chloro-4-cyano-2-iodo-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 643744-99-4 [5-chloro-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-2-phenylethynyl-phenyl]-carbamic acid tert-butyl ester 
• 643745-03-3 2-{5-[6-chloro-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-1H-indol-2-yl]-6-hydroxy-biphenyl-3-yl}-N,N-dimethyl-acetamide 
• 643744-98-3 [3-chloro-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Environmentally friendly and efficient: Iron-mediated reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to benzamidines

A new synthetic method is described for the mild and selective reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to amidines employing iron powder in aqueous medium. Its application is demonstrated in the synthesis of 1, a potent and selective urokinase-type plasminogen activator (uPA) inhibitor.