643744-98-3

Upstream product

• 869214-90-4 (5-chloro-4-cyano-2-iodo-phenyl)-carbamic acid tert-butyl ester 
• 380241-58-7 4-amino-2-chloro-5-iodobenzonitrile 
• 20925-27-3 4-amino-2-chlorobenzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 643744-97-2 [5-chloro-2-iodo-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Environmentally friendly and efficient: Iron-mediated reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to benzamidines

A new synthetic method is described for the mild and selective reduction of 3-methyl-5-aryl-1,2,4-oxadiazoles to amidines employing iron powder in aqueous medium. Its application is demonstrated in the synthesis of 1, a potent and selective urokinase-type plasminogen activator (uPA) inhibitor.