64376-02-9

Basic information

• Product Name: 2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-methyl-4-phenyl-
• CAS NO: 64376-02-9
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Mol File: 64376-02-9.mol

Chemical Properties

• CAS DataBase Reference: 2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-methyl-4-phenyl-(64376-02-9)
• EPA Substance Registry System: 2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-7-methyl-4-phenyl-(64376-02-9)

Safety Data

• Hazardous Substances Data: 64376-02-9(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 

Downstream Products

• 1261084-34-7 (4S)-5-acetyl-7-methyl-4-phenyl-4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-one 

Relevant articles and documents

Selective exploitation of acetoacetate carbonyl groups using imidazolium based ionic liquids: synthesis of 3-oxo-amides and substituted benzimidazoles

An unprecedented Br?nsted base ionic liquid tuned selective aminolysis of ester carbonyl of acetoacetates is demonstrated to achieve acetoacetamide derivatives. Other imidazolium ionic liquid performs an efficient cyclization catalysis involving acetoacetate-carbonyl groups and o-phenylenediamine at elevated temperature to produce benzimidazoles via C–C bond cleavage of intermediate 1,5-benzodiazepinones under solvent-free conditions.

Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon

Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.