64382-80-5

Usage

Uses

Used in Organic Synthesis:
2-Fluorobenzyl isothiocyanate is utilized as a synthetic intermediate for the preparation of various organic compounds. Its unique structure, featuring a fluorine atom, allows for specific reactivity and selectivity in chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Fluorobenzyl isothiocyanate is employed as a building block in the development of new drugs. Its incorporation into drug molecules can influence pharmacokinetic and pharmacodynamic properties, such as solubility, lipophilicity, and receptor binding affinity, which are critical for drug efficacy and safety.
Used in Agrochemicals and Herbicides:
2-Fluorobenzyl isothiocyanate also finds potential applications in the agrochemical sector, particularly in the development of herbicides. Its chemical properties may contribute to the design of novel herbicidal agents that can effectively control weed growth while minimizing environmental impact.
Safety Considerations:

InChI:InChI=1/C8H6FNS/c9-8-4-2-1-3-7(8)5-10-6-11/h1-4H,5H2

Upstream product

• 75-15-0 carbon disulfide 
• 89-99-6 2-fluorobenzylamine 

Downstream Products

• 61290-72-0 3-(2-Fluoro-benzyl)-1-(2-hydroxy-ethyl)-1-methyl-thiourea 
• 61290-44-6 1-(2-Fluoro-benzyl)-3-(2-hydroxy-ethyl)-thiourea 
• 61290-91-3 1-Allyl-3-(2-fluoro-benzyl)-thiourea 
• 74787-73-8 1-(2-Fluoro-benzyl)-3-(3-hydroxy-propyl)-thiourea 
• 1384521-73-6 1-(2-fluorobenzyl)-3-((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)thiourea 
• 1492902-38-1 2-(4-(2-fluorobenzyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)-N-(2-nitrophenyl)acetamide 
• 1492902-37-0 2-(4-(2-fluorobenzyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)-N-(2-fluorophenyl)acetamide 
• 1492902-36-9 N-(2-chlorophenyl)-2-(4-(2-fluorobenzyl)-5-isopropyl-4H-1,2,4-triazol-3-ylthio)acetamide 
• 1038384-04-1 C₁₂H₁₄FN₃S 
• 1492902-49-4 C₁₂H₁₆FN₃OS 
• 74788-04-8 (2-Fluoro-benzyl)-thiazolidin-(2Z)-ylidene-amine 

Relevant academic research and scientific papers

Synthesis and cytotoxic evaluation of quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or N-methyldithiocarbamate side Chains

We have previously found that the dithiocarbamate derivatives of quinazolin-4(3H)-one could act as cytotoxic agents against a panel of human tumor cell lines. To investigate the contribution of dithiocarbamate moiety to the cytotoxic activity, three series of novel quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or Nmethyldithiocarbamate side chains were synthesized and tested for their cytotoxic activity against human cancer cell lines A549, MCF-7, HeLa, HT29 and HCT-116 by MTT assay. The results showed that transformation of the dithiocarbamate moiety in lead compound I to thiocarbamate or thiourea led to a decrease or loss of cytotoxic activity. Some N-alkylated analogs of lead compound II preferentially inhibited the proliferation of A549 cells, although their potencies were not improved in comparison with the unalkylated counterparts. The structure-activity relationship obtained in this research will be beneficial for further synthesis and discovery of effective cytotoxic agents.