64388-29-0Relevant academic research and scientific papers
Regioselectivity of Pictet-Spengler cyclization: Synthesis of halotetrahydroisoquinolines
Cho, Su-Dong,Song, Sang-Yong,Hur, Eun-Joo,Chen, Ma,Joo, Woo-Hong,Falck,Yoon, Yong-Jin,Shin, Dong-Soo
, p. 6251 - 6253 (2007/10/03)
The regioselectivity of the Pictet-Spengler cyclization for the synthesis of isoquinolines depends on the aryl substituent at C-2. The ratio of halotetrahydroisoquinoline 4 to isoquinoline 3 increases with increasing electrophilicity of the aromatic ring (H?IBrCl).
