64392-59-2Relevant academic research and scientific papers
A versatile PIFA-mediated approach to structurally diverse pyrrolo(benzo)diazepines from linear alkynylamides
Pardo, Leticia M.,Tellitu, Imanol,Domínguez, Esther
experimental part, p. 5811 - 5818 (2010/09/11)
The addition of the hypervalent iodine reagent PIFA [phenyliodine(III) bis(trifluoroacetate)] to a series of properly substituted N-(3-aminopropyl) alkynylamides results in the efficient formation of a functionalized 5-aroyl-2-pyrrolidinone skeleton. By p
Concise preparation of novel tricyclic chemotypes: Fused hydantoin-benzodiazepines
Gunawan, Steven,Nichol, Gary S.,Chappeta, Shashi,Dietrich, Justin,Hulme, Christopher
experimental part, p. 4689 - 4692 (2010/09/20)
The following article describes a concise synthesis of a collection of 4,5-dihydro-1H-benzo[e][1,4]diazepines fused to a hydantoin ring. Molecular complexity and biological relevance are high and structures are generated in a mere three steps, employing the Ugi reaction to assemble diversity reagents. The protocol represents a novel UDC (Ugi-deprotect-cyclize) strategy employed in the Ugi-5-component CO2-mediated condensation, followed by further cyclization under basic conditions, to afford the fused hydantoin. Mechanistic caveats, dependent on the aldehydes of choice will be revealed and a facile oxidation of the final products to imidazolidenetriones is briefly discussed.
Study of biscarbamates derived from 2-aminobenzylamines as models for alcohol prodrugs
Papot, Sebastien,Bachmann, Christian,Combaud, Damien,Gesson, Jean-Pierre
, p. 4699 - 4708 (2007/10/03)
Unsubstituted N-arylcarbamate of title compound does not cyclize to the corresponding cyclic urea, with ROH liberation, under mild conditions (40°C). Substitution of the benzylic position by two methyl groups promotes slow cyclisation while N-methylation
