64411-76-3Relevant academic research and scientific papers
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones: A Correction
Veltri, Lucia,Amuso, Roberta,Cuocci, Corrado,Vitale, Paola,Gabriele, Bartolo
, p. 8743 - 8749 (2019)
The palladium-catalyzed carbonylation of 2-(propynylthio)benzimidazoles bearing a terminal triple bond leads to 2-methyl-1-thia-4a,9-diazafluoren-4-ones instead of the previously reported 3-methyl isomers, as unequivocally established by XRD analysis of a representative product. A correction is therefore provided here in order to rectify the previous erroneous assignment of the position of the methyl group. Moreover, the process has been generalized to substrates bearing an internal triple bond, which lead to 3-alkyl-2-methyl-1-thia-4a,9-diazafluoren-4-ones, whose structure was confirmed by XRD analysis of two representative derivatives.
N-Heterocyclic Carbene-Catalyzed in situ Activation of Alkynyl Acids for C?S Bond Formation: Access to Imidazo[2,1-b][1,3]thiazinones
Sun, Kewen,Jin, Shiyi,Zhu, Jindong,Zhang, Xinmiao,Gao, Maoyu,Zhang, Wanqi,Lu, Tao,Du, Ding
, p. 4515 - 4522 (2018/10/24)
Alkynyl acids are first utilized as alkynyl acylazolium precursors through an in situ activation strategy for the efficient construction of carbon-sulfur bond in a formal [3+3] annulation. This protocol offers a direct and rapid pathway for the synthesis of imidazo[2,1-b][1,3]thiazinone skeleton, a useful heterocyclic class frequently found in many bioactive compounds. This reaction also has the advantages of scalability, readily available materials, and simple manipulation in open air. (Figure presented.).
Addition Reactions of Diketene. IV. Reaction of Diketene with Thioureas, Thioamide, and Aminothiol
Sakamoto, Masanori,Akimoto, Takashi,Fukutomi, Kyoko,Ishii, Keitaro
, p. 2516 - 2521 (2007/10/02)
The reaction of benzimidazoline-2-thione (2) with diketene (1) gave the oxazine derivative 3 and the thiazine derivative 4.However, the reaction of 2-indolinethione (6) with diketene afforded only the thiazine derivative 7.On the other hand, no cyclized compound was obtained from 2-indolinone (8) and diketene.The reactions of N,N'-diphenylthiourea (11) and 2-aminobenzothiol (14) with diketene were also studied; 11 and 14 gave the thiouracil 12 and the benzothiazine 16, respectively.Keywords: diketene; thiourea; thioamide; aminothiol; cyclization; 1,3-oxazine; 1,3-thiazine; thiouracil; thiazepine.
