64416-49-5

Upstream product

• 6526-74-5 3-isopropylnitrobenzene 
• 645-00-1 m-iodonitrobenzene 
• 288321-56-2 1-Methyl-1-(1'-methylethenyl)silacyclobutane 
• 121-89-1 3-Nitroacetophenone 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 124-63-0 methanesulfonyl chloride 
• 21078-59-1 1-(α-chloro-isopropyl)-3-nitro-benzene 

Downstream Products

• 21078-59-1 1-(α-chloro-isopropyl)-3-nitro-benzene 
• 5369-16-4 meta-iso-propyl aniline 
• 23809-98-5 3-(prop-1-en-2-yl)aniline 
• 1326301-38-5 2-Methyl-2-(3-nitrophenyl)oxirane 
• 1234014-82-4 C₁₀H₁₁NO₂ 

Relevant academic research and scientific papers

Copper-catalyzed radical oxytrifluoromethylation of alkenyl oximes at ambient temperature

A mild and efficient copper-catalyzed radical oxytrifluoromethylation reaction of alkenyl oximes was successfully developed. The method provides a straightforward access to a wide range of CF3-containing isoxazolines in good to excellent yields.

Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis

We report the synthesis of phenylalanine-derived trifluoromethyl ketones for the in situ generation of dioxiranes for the purpose of oxidation catalysis. The key features of this synthesis include the use of a masked ketone strategy and a Negishi cross-coupling to access the parent amino acid. The derivatives can be readily incorporated into a peptide for use in oxidation chemistry and exhibit good stability and reactivity.

HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

Copper-carbene complexes as catalysts in the synthesis of functionalized styrenes and aliphatic alkenes

(NHC)-Cu (NHC = N-heterocyclic carbene) complexes efficiently catalyzed the methylenation of a variety of aliphatic and aromatic aldehydes and ketones in the presence of trimethylsilyldiazomethane, triphenylphosphine, and 2-propanol. The copper catalysts are not only inexpensive compared to rhodium complexes, but they also exhibit better functional group compatibility with aromatic aldehydes and ketones. Indeed very high yields were obtained for the formation of styrenes containing nitro, trifluoromethyl, amino, and ester groups, as well as for pyridine-, pyrrole-, and indole-substituted alkenes.

1-methyl-1-vinyl- and 1-methyl-1-(prop-2-enyl)silacyclobutane: Reagents for palladium-catalyzed cross-coupling reactions of aryl halides

1-Methyl-1-vinylsilacyclobutane (1) and 1-methyl-1(prop-2- enyl)silacyclobutane (2) undergo rapid and high yielding cross-coupling with aromatic halides. Many different substituents and patterns on the aromatic moiety are tolerated. All reactions can be r

Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C 1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II STR1 wherein R 2 represents carboxy or a group convertible thereto in vivo, R 6 is hydrogen and R 5 and R 7 represent C 1-6 alkyl or halogen, provided that R 5 and R 7 are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.