6443-74-9

Usage

Uses

Used in Pharmaceutical Industry:
(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Agricultural Chemical Industry:
(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile is also used as an intermediate in the synthesis of agricultural chemicals. Its properties contribute to the effectiveness of these products in various agricultural applications.
Used in Organic Electronic Materials Development:
(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile is used in the development of various organic electronic materials due to its unique conjugated structure and electronic properties. This makes it a promising candidate for applications in electronic devices and materials.
Used in Biological Research:
(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile has been studied for its potential biological activities, including anti-inflammatory and anticancer properties. Its potential in these areas is currently under investigation, which could lead to new therapeutic applications in the future.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 96047-26-6 2,3-bis-(4-methoxy-phenyl)-hexanenitrile 
• 107276-25-5 2,3-bis-(4-methoxy-phenyl)-propylamine 
• 6443-75-0 1,2-bis-(4-methoxy-phenyl)-propane 
• 343823-36-9 meso-2,3-bis(p-methoxyphenyl)succinonitrile 
• 2048-10-4 3,4-bis (4-methoxyphenyl)-1H-pyrrole 
• 170238-94-5 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 170238-96-7 methyl 3,4-bis(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-pyrrole-2-carboxylate 
• 72035-46-2 2,3-bis(4-methoxyphenyl)propanenitrile 
• 1428-67-7 2,3-bis-(4-hydroxyphenyl)propionitrile 
• 92497-66-0 2,3-bis(4-hydroxyphenyl)acrylonitrile 
• 74225-44-8 (2R,3S)-2,3-bis(4-methoxyphenyl)succinonitrile 
• 74225-44-8 rac-(2S,3S)-2,3-bis(4-methoxyphenyl)succinonitrile 
• 79754-48-6 4,5-bis-(p-methoxyphenyl)pentanoic acid 
• 79754-57-7 7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol 

Relevant academic research and scientific papers

Method for preparing alkenyl cyanide compounds

The invention discloses a method for preparing alkenyl cyanide compounds represented by formula II. Alkynes represented by formula I and a cyanation reagent are subjected to a reduction reaction represented by a formula shown in the description in an organic solvent under the protection of a gas at 20-100 DEG C under the action of a nickel catalyst, a reducing agent and H2O to prepare the alkenyl cyanide compounds represented by formula II. The preparation method of the invention, which adopts the cheap nickel as the catalytic system, has the advantages of simplicity in operation, mild reaction conditions, good compatibility of functional groups, wide application range of the substrate, high reaction efficiency and high yield, so the method has high application and promotion values.

Preparation method for acrylonitrile compound taking formamide as cyanogen source

The invention discloses a preparation method for an acrylonitrile compound. The preparation method comprises the steps of taking formamide as a cyanogen source and triggering hydrocyanation reaction of formamide and various alkynes under the action of a nickel catalyst, thereby generating the acrylonitrile compound. Reaction temperature is at 100-160 DEG C and reaction time is 6-24 hours. The method can overcome the defects of the traditional method for preparing acrylonitrile compound by using alkyne that operation steps are complex and virulent cyanogen source needs to be used as a reactionraw material. According to the method, simple, low-cost, green and nontoxic formamide is used as the cyanogen source, other dewatering agents (such as phosphorus pentoxide and phosphorus oxychloride)need not be additionally added and the acrylonitrile compound is generated through one-pot reaction; the method is simple in reaction condition, easy in operation, economical and high-efficient; the method shows excellent substrate universality; the acrylonitrile compound is insensitive to air, water and light; yield is high; products can be simply separated and purified; the preparation method has a bright application prospect.

ESTROGEN RECEPTOR LIGANDS, COMPOSITIONS AND METHODS RELATED THERETO

Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-β ligand (ΕΡβ ligand).

A Paal-Knorr approach to 3,4-diaryl-substituted pyrroles: Facile synthesis of lamellarins O and Q

A very simple, yet efficient synthetic methodology, to obtain 3,4-diaryl-substituted pyrroles is described. The approach is based on the Knoevenagel condensation between arylacetonitriles and substituted aromatic aldehydes, followed by conjugate addition of cyanide to afford succinonitriles in excellent yields. The products thus obtained were subjected to DIBAL-H reduction, followed by cyclization under acidic conditions to produce the corresponding pyrroles in good overall yields. The utility of this protocol is exemplified by the synthesis of the marine alkaloids lamellarins O and Q.

Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D

A high-yield six-step synthesis of sequirin D (1a), a naturally occurring norlignan, is described.Michael addition of deoxyanisoin (2) to acrylonitrile gives a ketonitrile (3), which on Wolff-Kishner reduction is reduced and hydrolysed in situ to 4,5-bis-