64431-93-2Relevant academic research and scientific papers
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors
Li, Bing,Pai, Ramdas,Cardinale, Steven C.,Butler, Michelle M.,Peet, Norton P.,Moir, Donald T.,Bavari, Sina,Bowlin, Terry L.
experimental part, p. 2264 - 2276 (2010/08/19)
NSC 240898 was previously identified as a botulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer Institute Open Repository diversity set. Two types of analogues have been synthesized and shown to inhibit Bo
Bisamidine compounds as antiproliferative agents
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, (2008/06/13)
Known bisamidine compounds are newly discovered to possess DNA methyltransferase inhibiting properties, making them useful for preparing pharmaceutical compositions useful as antiproliferative agents for treating a neoplastic or a non-neoplastic disease characterized by abnormally rapid proliferation of tissue involved in said disease; wherein said bisamidines comprise a compound of Formula (5.0.0): and a pharmaceutically acceptable salt thereof, wherein: —X is —C(R34)—; or —N—; —R23, R24, R28and R29are each independently —H; or —CH2— where R23and R24and R28and R29are taken together with the nitrogen atoms to which they are attached, to form an imidazolinyl group; and —R34is —H; or —CH3. A preferred species of Formula (5.0.0) is the following: 2-(4-Carbamimidoyl-phenyl)-1H-indole-6-carboxamidine.
