64445-82-5Relevant academic research and scientific papers
One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives
Iervasi, Erika,Lusardi, Matteo,Ponassi, Marco,Rosano, Camillo,Rotolo, Chiara,Spallarossa, Andrea
, (2022/02/05)
A series of highly functionalized pyrazole derivatives has been prepared by a one-pot, versatile and regioselective procedure. Pyrazoles 1–29 were tested in cell-based assay to assess their antiproliferative activity against a panel of tumour cells. Addit
Triflic acid-mediated N-heteroannulation of β-anilino-β-(methylthio)acrylonitriles: a facile synthesis of 4-amino-2-(methylthio)quinolines
Bandyopadhyay, Debashruti,Panigrahi, Adyasha,Peruncheralathan, S.,Radhakrishnan, Divya,Thirupathi, Annaram
supporting information, p. 8544 - 8553 (2021/10/20)
Various functionalised 4-amino-2-(methylthio)quinolines are synthesised through triflic acid-mediated N-heteroannulation of α-functionalized-β-anilino-β-(methylthio)acrylonitriles for the first time. The N-heteroannulation process is highly chemoselective and has mild reaction conditions. However, this process fails in the absence of the β-methylthio group in the acrylonitriles. In addition, a new double N-heteroannulation process is demonstrated to synthesise indolo[3,2-c]quinolines from non-heterocyclic precursors. Natural product isocryptolepine is synthesised in four steps from an acyclic precursor.
V2O5/SiO2 as an efficient catalyst in the synthesis of 5-amino-pyrazole derivatives under solvent free condition
Khatab, Tamer K.,Hassan, Ashraf S.,Hafez, Taghrid S.
, p. 135 - 142 (2019/03/21)
An efficient and facile approach for the synthesis of 5-aminopyrazoles from ketene S,N-acetal and hydrazine hydrate via catalytic reaction under solvent free condition has been described. V2O5/SiO2 as a heterogeneous catalyst was prepared and characterize
S-glycosides in medicinal chemistry: Novel synthesis of cyanoethylene thioglycosides and their pyrazole derivatives
Elgemeie, Galal,Fathy, Nahed,Zaghary, Wafaa,Farag, Ayman
, p. 198 - 212 (2017/02/15)
A one-pot reaction of a sodium 2-cyanoethylene-1-thiolate salt with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides affords a new class of cyanoethylene thioglycosides. The conversion to the corresponding 5-aminopyrazoles confirms the E-co
Preparation of thieno[2,3-b]pyrroles starting from ketene-N,S-acetals
Sommen, Geoffroy,Comel, Alain,Kirsch, Gilbert
, p. 1557 - 1564 (2007/10/03)
Thieno[2,3-b]pyrroles 4 can easily be synthesised in two different ways by using phenyl isothiocyanate and activated methylene compounds. The priority of the formation of the thiophene or pyrrole ring is investigated.
An improved method for the synthesis of aminothiophenes precursors of thieno[2,3-b]pyrrole
Sommen, Geoffroy,Comel, Alain,Kirsch, Gilbert
, p. 257 - 259 (2007/10/03)
Thiophenes 2 can easily be synthesized in two steps by using phenyl isothiocyanate and activated methylene compounds.
