64460-41-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyridin-4-ylmethanamine hydrochloride is used as a building block for the synthesis of pharmaceutical compounds. Its unique structure allows it to be incorporated into various drug molecules, contributing to the development of new therapeutic agents.
Used in Coordination Chemistry:
In the field of coordination chemistry, Pyridin-4-ylmethanamine hydrochloride is used as a ligand. Its ability to form coordination complexes with metal ions makes it a valuable component in the design of metal-organic frameworks and other coordination compounds with potential applications in catalysis, sensing, and materials science.
Used as a Reagent in Organic Synthesis:
Pyridin-4-ylmethanamine hydrochloride serves as a reagent in organic synthesis, facilitating various chemical transformations. Its presence can enhance the reactivity and selectivity of certain reactions, leading to the formation of desired products with improved efficiency.
Used as a Catalyst in Chemical Reactions:
Pyridin-4-ylmethanamine hydrochloride also functions as a catalyst in chemical reactions, promoting the conversion of reactants to products. Its catalytic activity can accelerate reaction rates and enhance the yield of target compounds, making it a useful tool in the synthesis of various organic and inorganic materials.
Used in Crop Protection and Agrochemicals:
Pyridin-4-ylmethanamine hydrochloride has potential applications in the field of crop protection and agrochemicals. Its chemical properties may contribute to the development of new pesticides, herbicides, or other agrochemicals that can help improve agricultural productivity and protect crops from pests and diseases.

InChI:InChI=1/C6H8N2.ClH/c7-5-6-1-3-8-4-2-6;/h1-4H,5,7H2;1H

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 1453-82-3 isonicotinamide 
• 1822-51-1 4-picolylchloride hydrochloride 
• 110-86-1 pyridine 
• 85127-48-6 4-(1-acetyl-4(1H)-pyridylidene)-2-methyl-2-oxazolin-5-one 

Downstream Products

• 1257425-12-9 4-(4-methoxyphenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 
• 1257425-13-0 4-(4-chlorophenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 
• 1257425-11-8 3-(pyridine-4-ylmethyl)-4-p-tolylthiazol-2(3H)imine 
• 1257425-10-7 4-phenyl-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine 

Relevant academic research and scientific papers

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol

The atom economical synthesis of hydrogen halide salts of primary amines, directly from the corresponding halides, avoids the production of significant amounts of secondary amine side products, and requires only evaporation of the solvent to access the products in yields generally greater than 90%. The procedure uses microwave irradiation in 7 M ammonia in methanol (Aldrich) at 130°C from 0.5 to 2.5h and works on a variety of alkyl halides, as well as mesylates and tosylates. Benzylamines are obtained from benzyl halides without significant amounts of the secondary amine side products that result without microwave heating. Direct isolation of even highly volatile primary amines as their hydrogen halide salts makes the method ideal for use in parallel synthesis.

A Facile Preparation of 4-(1-acetyl-4(1H)-pyridylidene)-2-oxazolin-5-ones

4-(1-Acetyl-4(1H)-pyridylidene)-2-oxazolin-5-ones were prepared by the reaction of acylglycines with pyridine and acetic anhydride under oxygen.Acidic and alkaline hydrolysis of 2-oxazolin-5-ones provided oxazole derivatives, pyridine derivatives and carboxylic acids.